{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:05:31Z","timestamp":1789628731423,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["950-231498"],"award-info":[{"award-number":["950-231498"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["202209MRR-489062-MPX-CDAA-168421"],"award-info":[{"award-number":["202209MRR-489062-MPX-CDAA-168421"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["202209PPE-491319-VVP-CDAA-168421"],"award-info":[{"award-number":["202209PPE-491319-VVP-CDAA-168421"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Variola virus (VARV), the etiological agent of smallpox, had enormous impacts on global health prior to its eradication. In the absence of global vaccination programs, mpox virus (MPXV) has become a growing public health threat that includes endemic and nonendemic regions across the globe. While human mpox resembles smallpox in clinical presentation, there are considerable knowledge gaps regarding conserved molecular pathogenesis between these 2 orthopoxviruses. Thus, we sought to compare MPXV and VARV infections in human monocytes through kinome analysis. We performed a longitudinal analysis of host cellular responses to VARV infection in human monocytes as well as a comparative analysis to clade I MPXV-mediated responses. While both viruses elicited strong activation of cell responses early during infection as compared to later time points, several key differences in cell signaling events were identified and validated. These observations will help in the design and development of panorthopoxvirus therapeutics.<\/jats:p>","DOI":"10.1093\/infdis\/jiad516","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T22:58:11Z","timestamp":1700780291000},"page":"S265-S274","source":"Crossref","is-referenced-by-count":6,"title":["Variola Virus and Clade I Mpox Virus Differentially Modulate Cellular Responses Longitudinally in Monocytes During Infection"],"prefix":"10.1093","volume":"229","author":[{"given":"Victoria","family":"Wahl","sequence":"first","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Frederick, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria A","family":"Olson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley V","family":"Kondas","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B","family":"Jahrling","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Frederick, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger K","family":"Damon","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-7084","authenticated-orcid":false,"given":"Jason","family":"Kindrachuk","sequence":"additional","affiliation":[{"name":"Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Frederick, Maryland , USA"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"2024032619384264600_jiad516-B1","author":"Fenner","year":"1988"},{"issue":"Suppl 1","key":"2024032619384264600_jiad516-B2","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1038\/sj.embor.embor860","article-title":"Genetic engineering and biological weapons. 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