{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:37:59Z","timestamp":1779165479009,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2T32AI052073-16A1"],"award-info":[{"award-number":["2T32AI052073-16A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["6 NU50CK000498-04-03"],"award-info":[{"award-number":["6 NU50CK000498-04-03"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Los Angeles County Department of Public Health established a surveillance system to identify complicated (advanced human immunodeficiency virus [HIV] or hospitalized) mpox cases. From 1 August to 30 November 2022, we identified 1581 mpox cases, of which 134 (8.5%) were complicated. A subset of 8 cases did not recover after either initiating or completing a course of oral tecovirimat. All 8 patients were HIV positive and had advanced HIV (CD4 count &amp;lt;200 cells\/\u03bcL). We identified 8 distinct mutations previously associated with tecovirimat resistance in specimens collected from 6 patients. Ongoing surveillance of viral evolution requires close coordination between health departments and frontline providers.<\/jats:p>","DOI":"10.1093\/infdis\/jiad517","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T21:00:40Z","timestamp":1700773240000},"page":"S249-S254","source":"Crossref","is-referenced-by-count":9,"title":["Surveillance of Complicated Mpox Cases Unresponsive to Oral Tecovirimat in Los Angeles County, 2022"],"prefix":"10.1093","volume":"229","author":[{"given":"Abraar","family":"Karan","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Stanford University , Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naman","family":"Shah","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M","family":"Garrigues","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jemma","family":"Alarc\u1f79n","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peera","family":"Hemarajata","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E","family":"Finn","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Poortinga","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phoebe","family":"Danza","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Terashita","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M","family":"Green","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Balter","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health , Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"2024032619383170400_jiad517-B1","first-page":"1814","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Petersen","year":"2020","edition":"9th ed"},{"key":"2024032619383170400_jiad517-B2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox virus infection in humans across 16 countries\u2014April\u2013June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N Engl J Med"},{"key":"2024032619383170400_jiad517-B3","author":"Centers for Disease Control and Prevention"},{"key":"2024032619383170400_jiad517-B4","author":"US Food and Drug Administration"},{"key":"2024032619383170400_jiad517-B5","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1056\/NEJMc2214921","article-title":"An mpox-related death in the United States","volume":"388","author":"Alarc\u00f3n","year":"2023","journal-title":"N Engl J Med"},{"key":"2024032619383170400_jiad517-B6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.15585\/mmwr.mm7209a4","article-title":"Interim clinical treatment considerations for severe manifestations of mpox\u2014United States, February 2023","volume":"72","author":"Rao","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024032619383170400_jiad517-B7","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41564-022-01269-8","article-title":"Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations","volume":"7","author":"Frenois-Veyrat","year":"2022","journal-title":"Nat Microbiol"},{"key":"2024032619383170400_jiad517-B8","author":"US Food and Drug Administration"},{"key":"2024032619383170400_jiad517-B9","doi-asserted-by":"crossref","first-page":"e0056823","DOI":"10.1128\/aac.00568-23","article-title":"Identification of tecovirimat resistance-associated mutations in human monkeypox virus\u2014Los Angeles County","volume":"67","author":"Garrigues","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"2024032619383170400_jiad517-B10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(23)00273-8","article-title":"; SHARE-NET Writing Group. Mpox in people with advanced HIV infection: a global case series","volume":"401","author":"Mitj\u00e0","year":"2023","journal-title":"Lancet"},{"key":"2024032619383170400_jiad517-B11","author":"Centers for Disease Control and Prevention"},{"key":"2024032619383170400_jiad517-B12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/cid\/ciad147","article-title":"A case of mpox reinfection","volume":"77","author":"Musumeci","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2024032619383170400_jiad517-B13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0140-6736(22)01106-0","article-title":"Monkeypox genomic surveillance will challenge lessons learned from SARS-CoV-2","volume":"400","author":"Pfaff","year":"2022","journal-title":"Lancet"},{"key":"2024032619383170400_jiad517-B14","doi-asserted-by":"crossref","first-page":"e0165522","DOI":"10.1128\/jcm.01655-22","article-title":"Identification of human monkeypox virus genome deletions that impact diagnostic assays","volume":"60","author":"Garrigues","year":"2022","journal-title":"J Clin Microbiol"},{"key":"2024032619383170400_jiad517-B15","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41591-022-01907-y","article-title":"Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus","volume":"28","author":"Isidro","year":"2022","journal-title":"Nat Med"},{"key":"2024032619383170400_jiad517-B16","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S1473-3099(22)00876-3","article-title":"The response of mpox-associated inflammatory syndrome to steroid therapy","volume":"23","author":"Arias","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2024032619383170400_jiad517-B17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1056\/NEJMc2212136","article-title":"Drug sensitivity of currently circulating mpox viruses","volume":"388","author":"Bojkova","year":"2023","journal-title":"N Engl J Med"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiad517\/53692979\/jiad517.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/229\/Supplement_2\/S249\/57094521\/jiad517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/229\/Supplement_2\/S249\/57094521\/jiad517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:06:39Z","timestamp":1711483599000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/229\/Supplement_2\/S249\/7442652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":17,"journal-issue":{"issue":"Supplement_2","published-online":{"date-parts":[[2023,11,23]]},"published-print":{"date-parts":[[2024,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiad517","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,15]]},"published":{"date-parts":[[2023,11,23]]}}}