{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:51:59Z","timestamp":1765828319640,"version":"build-2065373602"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08434"],"award-info":[{"award-number":["22K08434"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kochi Shin-kin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cutavirus (CuV) is associated with mycosis fungoides; however, the CuV status in parapsoriasis en plaques (PP), a premalignant inflammatory condition of mycosis fungoides, has not been fully delineated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifty-five Japanese patients with chronic inflammatory skin diseases, including 13 patients with PP, were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CuV DNA was detected significantly more frequently in biopsies of the lesional skin from patients with PP (38%; 4 of 13) than in those from patients with other inflammatory skin diseases (2%; 1 of 42; P = .009). All CuV-positive PP cases were of the large-plaque parapsoriasis (LPP) subtype. The viral loads ranged from 83 450 to 2 164 170 copies\/103 cells. We recovered near\u2013full-length CuV sequences from the CuV-positive LPP biopsies, all of which were of the Japanese\/Asian genotype. The CuV genome appeared to be present within lymphoid cells infiltrating the epidermis and dermis. CuV NS1 and VP1 gene transcripts were also detected in the affected tissues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The detection of high levels of CuV DNA with the expression of viral mRNA suggests a potential role for CuV in the pathogenesis of LPP, making it necessary to study further the impact of CuV, especially regarding the viral genotype, on the outcomes of patients with CuV-positive LPP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad521","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:02:12Z","timestamp":1700755332000},"page":"109-119","source":"Crossref","is-referenced-by-count":4,"title":["Cutavirus Infection in Large-Plaque Parapsoriasis, a Premalignant Condition of Mycosis Fungoides"],"prefix":"10.1093","volume":"230","author":[{"given":"Yumiko","family":"Hashida","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infection, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Ujihara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]},{"name":"Science Research Center, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-2068","authenticated-orcid":false,"given":"Masanori","family":"Daibata","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection, Kochi Medical School, Kochi University , Nankoku, Kochi ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"2025093012520584300_jiad521-B1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.virol.2016.06.013","article-title":"A new protoparvovirus in human fecal 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