{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:32:24Z","timestamp":1792186344378,"version":"4.4.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["775N91019D00024"],"award-info":[{"award-number":["775N91019D00024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261201500003I"],"award-info":[{"award-number":["HHSN261201500003I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization.<\/jats:p>","DOI":"10.1093\/infdis\/jiad532","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T18:30:32Z","timestamp":1701282632000},"page":"S243-S248","source":"Crossref","is-referenced-by-count":23,"title":["Prolonged Mpox Disease in People With Advanced HIV: Characterization of Mpox Skin Lesions"],"prefix":"10.1093","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-8834","authenticated-orcid":false,"given":"Jesse","family":"O\u2019Shea","sequence":"first","affiliation":[{"name":"Mpox Emergency Response Team, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-6412","authenticated-orcid":false,"given":"Jason","family":"Zucker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Columbia University Irving Medical Center , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Stampfer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Cash-Goldwasser","sequence":"additional","affiliation":[{"name":"Mpox Emergency Response Team, Centers for Disease Control and Prevention , Atlanta, Georgia"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal S","family":"Minhaj","sequence":"additional","affiliation":[{"name":"Mpox Emergency Response Team, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Dretler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Atlanta and Emory Decatur Hospital , Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Cheeley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Columbia University Irving Medical Center , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie 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