{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:06:00Z","timestamp":1790791560320,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Host-response biomarkers to differentiate bacterial from viral etiology in children with respiratory infections have shown high accuracies, but are understudied in Mycoplasma pneumoniae (Mp) infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared BV scores (0\u201334 indicating viral etiology, and 66\u2013100 indicating bacterial etiology), tumor necrosis factor\u2013related apoptosis-inducing ligand (TRAIL; pg\/mL), interferon-\u03b3 inducible protein 10 (IP-10; pg\/mL), and C-reactive protein (CRP; mg\/L) serum levels between Mp-positive (Mp+) and Mp-negative (Mp\u2212) community-acquired pneumonia (CAP) patients. We performed receiver operating characteristic (ROC) curve analyses for clinical features and biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 80 CAP patients (median age, 6.3 years; 57.5% male), 26 had Mp+CAP. In Mp+CAP patients, compared to Mp\u2212CAP patients, BV scores were lower (14.0 [3.0\u201327.8] vs 54.0 [12.0\u201384.8]; P = .0008), TRAIL levels were higher (86.5 [67.4\u2013123.0] vs 65.5 [42.5\u2013103.9]; P = .025), CRP levels were lower (12.9 [4.0\u201322.3] vs 36.7 [13.0\u2013132.8]; P = .0019), and IP-10 levels were comparable (366.0 [150.2\u2013603.8] vs 331.0 [154.3\u2013878.8]; P = .73) (all median [interquartile range]). ROC analyses yielded a comparable discriminatory accuracy for the combination of age, fever duration, and duration of respiratory symptoms, with either procalcitonin or BV score (area under the ROC curve, 0.87 vs 0.86; P = .94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with Mp+CAP have atypically low, viral levels of the BV score, underscoring the complementary role of microbiological testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiad573","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:23:58Z","timestamp":1702423438000},"page":"e247-e253","source":"Crossref","is-referenced-by-count":21,"title":["Combinatorial Host-Response Biomarker Signature (BV Score) and Its Subanalytes TRAIL, IP-10, and C-Reactive Protein in Children With\n                    <i>Mycoplasma pneumoniae<\/i>\n                    Community-Acquired Pneumonia"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-2567","authenticated-orcid":false,"given":"Cihan","family":"Papan","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Homburg, Saarland University, Germany"},{"name":"Institute for Hygiene and Public Health, University Hospital Bonn , Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semjon","family":"Sidorov","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Greiter","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Homburg, Saarland University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren L","family":"Becker","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Homburg, Saarland University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M","family":"Meyer Sauteur","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital 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