{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:07:55Z","timestamp":1783649275724,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["DZL"],"award-info":[{"award-number":["DZL"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"German Center for Lung Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Staphylococcus aureus is a prevalent pathogen in pneumonia and harbors glycolipids, which may serve as molecular patterns in Mincle (macrophage-inducible C-type lectin)\u2013dependent pathogen recognition. We examined the role of Mincle in lung defense against S aureus in wild-type (WT), Mincle knockout (KO), and Mincle transgenic (tg) mice. Two glycolipids, glucosyl-diacylglycerol (Glc-DAG) and diglucosyl-diacylglycerol (Glc2-DAG), were purified, of which only Glc-DAG triggered Mincle reporter cell activation and professional phagocyte responses. Proteomic profiling revealed that Glc2-DAG blocked Glc-DAG\u2013induced cytokine responses, thereby acting as inhibitor of Glc-DAG\/Mincle signaling. WT mice responded to S aureus with a similar lung pathology as Mincle KO mice, most likely due to Glc2-DAG\u2013dependent inhibition of Glc-DAG\/Mincle signaling. In contrast, ectopic Mincle expression caused severe lung pathology in S aureus\u2013infected mice, characterized by bacterial outgrowth and fatal pneumonia. Collectively, Glc2-DAG inhibits Glc-DAG\/Mincle\u2013dependent responses in WT mice, whereas sustained Mincle expression overrides Glc2-DAG\u2013mediated inhibitory effects, conferring increased host susceptibility to S aureus.<\/jats:p>","DOI":"10.1093\/infdis\/jiad608","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T14:23:42Z","timestamp":1703946222000},"page":"198-208","source":"Crossref","is-referenced-by-count":9,"title":["Ectopic Expression of C-Type Lectin Mincle Renders Mice Susceptible to Staphylococcal Pneumonia"],"prefix":"10.1093","volume":"230","author":[{"given":"Femke D","family":"Hollwedel","sequence":"first","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Maus","sequence":"additional","affiliation":[{"name":"Division of Experimental Pneumology, Hannover Medical School , Hannover , 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