{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:46:43Z","timestamp":1771526803020,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Center of Infectious Disease Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S\u2013specific CD8+ T-cell epitope in an HLA-A*03:01\/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction. As evidence from MERS-CoV infection suggests a protective role of long-lasting CD8+ T-cell responses, the identification of epitopes will facilitate longitudinal analyses of vaccine-induced T-cell immunity.<\/jats:p>","DOI":"10.1093\/infdis\/jiad612","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:06:49Z","timestamp":1704852409000},"page":"e327-e332","source":"Crossref","is-referenced-by-count":1,"title":["Identification of a Spike-Specific CD8+ T-Cell Epitope Following Vaccination Against the Middle East Respiratory Syndrome Coronavirus in Humans"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-9029","authenticated-orcid":false,"given":"Caroline E","family":"Harrer","sequence":"first","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-4358","authenticated-orcid":false,"given":"Leonie","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anahita","family":"Fathi","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"},{"name":"First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf , Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Lassen","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My L","family":"Ly","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine E","family":"Zinser","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-9540","authenticated-orcid":false,"given":"Timo","family":"Wolf","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital, Department of Internal Medicine II, Division of Infectious Diseases , Frankfurt 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Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-9224","authenticated-orcid":false,"given":"Marylyn M","family":"Addo","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf"},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine"},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the MVA-MERS-S Study 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