{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:10:14Z","timestamp":1791227414270,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome-Health Research Board"},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["15\/IA\/3041"],"award-info":[{"award-number":["15\/IA\/3041"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["16\/IA\/4468"],"award-info":[{"award-number":["16\/IA\/4468"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["12\/RI\/2340-7"],"award-info":[{"award-number":["12\/RI\/2340-7"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["115910"],"award-info":[{"award-number":["115910"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["202846\/Z\/16\/Z"],"award-info":[{"award-number":["202846\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union Horizon 2020 Research and Innovation Programme"},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The objective was to determine if antigen-specific tissue-resident memory T (TRM) cells persist in respiratory tissues of adults immunized as children with whole-cell pertussis (wP) or acellular pertussis (aP) vaccines. Mononuclear cells from tonsil or nasal tissue cells were cultured with Bordetella pertussis antigens and TRM cells quantified by flow cytometry. Adults immunized with wP vaccines as children had significantly more interleukin 17A (IL-17A) and interferon-\u03b3 (IFN-\u03b3)\u2013producing TRM cells that respond to B. pertussis antigens in respiratory tissues when compared with aP-primed donors. Our findings demonstrate that wP vaccines induce CD4 TRM cells that can persist in respiratory tissues for decades.<\/jats:p>","DOI":"10.1093\/infdis\/jiae034","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T20:27:30Z","timestamp":1706646450000},"page":"e518-e523","source":"Crossref","is-referenced-by-count":30,"title":["IL-17 and IFN-\u03b3\u2013producing Respiratory Tissue-Resident Memory CD4 T Cells Persist for Decades in Adults Immunized as Children With Whole-Cell Pertussis Vaccines"],"prefix":"10.1093","volume":"230","author":[{"given":"Karen N","family":"McCarthy","sequence":"first","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland"},{"name":"Children's Health Ireland , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hone","sequence":"additional","affiliation":[{"name":"Children's Health Ireland , Dublin , Ireland"},{"name":"Department of Otolaryngology, Royal Victoria Eye and Ear Hospital , Dublin , Ireland"},{"name":"School of Medicine, University College Dublin , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-8222","authenticated-orcid":false,"given":"Kingston H G","family":"Mills","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2024092316155958400_jiae034-B1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2500\/aap.2021.42.210065","article-title":"The global burden of vaccine-preventable infectious diseases in children less than 5 years of age: implications for COVID-19 vaccination. How can we do better?","volume":"42","author":"Frenkel","year":"2021","journal-title":"Allergy Asthma Proc"},{"key":"2024092316155958400_jiae034-B2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3201\/eid0605.000512","article-title":"Pertussis infection in fully vaccinated children in day-care centers, Israel","volume":"6","author":"Srugo","year":"2000","journal-title":"Emerg Infect Dis"},{"key":"2024092316155958400_jiae034-B3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.1314688110","article-title":"Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model","volume":"111","author":"Warfel","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024092316155958400_jiae034-B4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/22221751.2018.1564630","article-title":"Immunization with whole cell but not acellular pertussis vaccines primes CD4 T(RM) cells that 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