{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:18Z","timestamp":1787317998852,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013275","name":"Serrapilheira Institute","doi-asserted-by":"publisher","award":["R-2011\u201337433"],"award-info":[{"award-number":["R-2011\u201337433"]}],"id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcriptomics has been used to evaluate immune responses during malaria in diverse cohorts worldwide. However, the high heterogeneity of cohorts and poor generalization of transcriptional signatures reported in each study limit their potential clinical applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compiled 28 public data sets containing 1556 whole-blood or peripheral blood mononuclear cell transcriptome samples. We estimated effect sizes with Hedge's g value and the DerSimonian-Laird random-effects model for meta-analyses of uncomplicated malaria. Random forest models identified gene signatures that discriminate malaria from bacterial infections or malaria severity. Parasitological, hematological, immunological, and metabolomics data were used for validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 3 gene signatures: the uncomplicated Malaria Meta-Signature, which discriminates Plasmodium falciparum malaria from uninfected controls; the Malaria or Bacteria Signature, which distinguishes malaria from sepsis and enteric fever; and the cerebral Malaria Meta-Signature, which characterizes individuals with cerebral malaria. These signatures correlate with clinical hallmark features of malaria. Blood transcription modules indicate immune regulation by glucocorticoids, whereas cell development and adhesion are associated with cerebral malaria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transcriptional meta-signatures reflecting immune cell responses provide potential biomarkers for translational innovation and suggest critical roles for metabolic regulators of inflammation during malaria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiae041","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T15:41:04Z","timestamp":1706110864000},"page":"e474-e485","source":"Crossref","is-referenced-by-count":4,"title":["Host Transcriptional Meta-signatures Reveal Diagnostic Biomarkers for\n                    <i>Plasmodium falciparum<\/i>\n                    Malaria"],"prefix":"10.1093","volume":"230","author":[{"given":"N\u00e1gila Isleide","family":"Silva","sequence":"first","affiliation":[{"name":"Departamento de Bioci\u00eancias e Tecnologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s , Goi\u00e2nia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Felipe Loyola","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de Bioci\u00eancias e Tecnologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s , Goi\u00e2nia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Fernandes","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Bioci\u00eancias e Tecnologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s , Goi\u00e2nia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Gon\u00e7alves","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Departamento de Bioci\u00eancias e Tecnologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s , Goi\u00e2nia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-2688","authenticated-orcid":false,"given":"Luiz Gustavo","family":"Gardinassi","sequence":"additional","affiliation":[{"name":"Departamento de Bioci\u00eancias e Tecnologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s , Goi\u00e2nia , Brazil"},{"name":"Departamento de Enfermagem Materno-Infantil e Sa\u00fade P\u00fablica, Escola de Enfermagem de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto , 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