{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:51:40Z","timestamp":1787064700812,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Plan","award":["2021YFA1300902"],"award-info":[{"award-number":["2021YFA1300902"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170009"],"award-info":[{"award-number":["82170009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Science Fund for Distinguished Young Scholars","award":["440300231181537705092"],"award-info":[{"award-number":["440300231181537705092"]}]},{"name":"State Key Laboratory of Respiratory Diseases Open Project","award":["SKLRD-OP-202324"],"award-info":[{"award-number":["SKLRD-OP-202324"]}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["KCXFZ20211020163545004"],"award-info":[{"award-number":["KCXFZ20211020163545004"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["RCJC20221008092726022"],"award-info":[{"award-number":["RCJC20221008092726022"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["LCYX20220620105200001"],"award-info":[{"award-number":["LCYX20220620105200001"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Scientific and Technological Foundation","award":["AA22096027"],"award-info":[{"award-number":["AA22096027"]}]},{"name":"China National GeneBank"},{"name":"Shenzhen Key Laboratory of Single-Cell Omics","award":["ZDSYS20190902093613831"],"award-info":[{"award-number":["ZDSYS20190902093613831"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coinfection of human immunodeficiency virus type 1 (HIV-1) is the most significant risk factor for tuberculosis (TB). The immune responses of the lung are essential to restrict the growth of Mycobacterium tuberculosis and avoid the emergence of the disease. Nevertheless, there is still limited knowledge about the local immune response in people with HIV-1\u2013TB coinfection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed single-cell RNA sequencing (scRNA-seq) on bronchoalveolar lavage fluid from 9 individuals with HIV-1\u2013TB coinfection and 10 with pulmonary TB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 19 058 cells were grouped into 4 major cell types: myeloid cells, T\/natural killer (NK) cells, B cells, and epithelial cells. The myeloid cells and T\/NK cells were further divided into 10 and 11 subsets, respectively. The proportions of dendritic cell subsets, CD4+ T cells, and NK cells were lower in the HIV-1\u2013TB coinfection group compared to the TB group, while the frequency of CD8+ T cells was higher. Additionally, we identified numerous differentially expressed genes between the CD4+ and CD8+ T-cell subsets between the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIV-1 infection not only affects the abundance of immune cells in the lungs but also alters their functions in patients with pulmonary TB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiae042","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:34:22Z","timestamp":1706081662000},"page":"e524-e535","source":"Crossref","is-referenced-by-count":8,"title":["Uncovering the Bronchoalveolar Single-Cell Landscape of Patients With Pulmonary Tuberculosis With Human Immunodeficiency Virus Type 1 Coinfection"],"prefix":"10.1093","volume":"230","author":[{"given":"Guohui","family":"Xiao","sequence":"first","affiliation":[{"name":"National Clinical 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