{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:15:29Z","timestamp":1792181729150,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The most recent Sudan virus (SUDV) outbreak in Uganda was first detected in September 2022 and resulted in 164 laboratory-confirmed cases and 77 deaths. There are no approved vaccines against SUDV. Here, we investigated the protective efficacy of ChAdOx1-biEBOV in cynomolgus macaques using a prime or a prime-boost regimen. ChAdOx1-biEBOV is a replication-deficient simian adenovirus vector encoding SUDV and Ebola virus (EBOV) glycoproteins (GPs). Intramuscular vaccination induced SUDV and EBOV GP-specific immunoglobulin G responses and neutralizing antibodies. Upon challenge with SUDV, vaccinated animals showed signs of disease like those observed in control animals, and no differences in survival outcomes were measured among all 3 groups. Viral load in blood samples and in tissue samples obtained after necropsy were not significantly different between groups. Overall, this study highlights the importance of evaluating vaccines in multiple animal models and demonstrates the importance of understanding protective efficacy in both animal models and human hosts.<\/jats:p>","DOI":"10.1093\/infdis\/jiae056","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T16:19:32Z","timestamp":1706631572000},"page":"1083-1092","source":"Crossref","is-referenced-by-count":14,"title":["A Bivalent Adenovirus-Vectored Vaccine Induces a Robust Humoral Response, but Does Not Protect Cynomolgus Macaques Against a Lethal Challenge With Sudan Virus"],"prefix":"10.1093","volume":"230","author":[{"given":"Sarah","family":"van Tol","sequence":"first","affiliation":[{"name":"Laboratory of Virology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Laboratory of 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Virology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F","family":"Rhoderick","sequence":"additional","affiliation":[{"name":"Laboratory of Virology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Makinson","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Carmody","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Myers","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Lovaglio","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Smith","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Okumura","sequence":"additional","affiliation":[{"name":"Laboratory of Virology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Shaia","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Saturday","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-9587","authenticated-orcid":false,"given":"Andrea","family":"Marzi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lambe","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent J","family":"Munster","sequence":"additional","affiliation":[{"name":"Laboratory of 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Organ"},{"key":"2024111514561717200_jiae056-B3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1046\/j.1365-3156.2002.00944.x","article-title":"An outbreak of Ebola in Uganda","volume":"7","author":"Okware","year":"2002","journal-title":"Trop Med Int Health"},{"key":"2024111514561717200_jiae056-B4","first-page":"370","article-title":"Outbreak of Ebola haemorrhagic fever in Yambio, South Sudan, April\u2013June 2004","volume":"80","year":"2005","journal-title":"Wkly Epidemiol Rec"},{"key":"2024111514561717200_jiae056-B5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virol.2013.04.014","article-title":"Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012","volume":"442","author":"Albari\u00f1o","year":"2013","journal-title":"Virology"},{"key":"2024111514561717200_jiae056-B6","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3201\/eid1809.111536","article-title":"Reemerging Sudan Ebola virus disease in Uganda, 2011","volume":"18:","author":"Shoemaker","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"2024111514561717200_jiae056-B7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijid.2023.01.008","article-title":"Sudan virus disease outbreak in Uganda in 2022: the case of patient zero","volume":"128","author":"Musoke","year":"2023","journal-title":"Int J Infect Dis"},{"key":"2024111514561717200_jiae056-B8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.15585\/mmwr.mm7145a5","article-title":"Notes from the field: outbreak of Ebola virus disease caused by Sudan ebolavirus\u2014Uganda, August\u2013October 2022","volume":"71","author":"Kiggundu","year":"2022","journal-title":"MMWR Morb 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