{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:27:15Z","timestamp":1791959235438,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL105427"],"award-info":[{"award-number":["HL105427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI111914-02"],"award-info":[{"award-number":["AI111914-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI123780"],"award-info":[{"award-number":["AI123780"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Molecular Microbiology"},{"DOI":"10.13039\/100011912","name":"Washington University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early innate immune responses play an important role in determining the protective outcome of Mycobacterium tuberculosis (Mtb) infection. Nuclear factor \u03baB (NF-\u03baB) signaling in immune cells regulates the expression of key downstream effector molecules that mount early antimycobacterial responses. Using conditional knockout mice, we studied the effect of abrogation of NF-\u03baB signaling in different myeloid cell types and its impact on Mtb infection. Our results show that the absence of IKK2-mediated signaling in all myeloid cells resulted in increased susceptibility to Mtb infection. In contrast, the absence of IKK2-mediated signaling in CD11c+ myeloid cells induced early proinflammatory cytokine responses, enhanced the recruitment of myeloid cells, and mediated early resistance to Mtb. Abrogation of IKK2 in MRP8-expressing neutrophils did not affect disease pathology or Mtb control. Thus, we describe an early immunoregulatory role for NF-\u03baB signaling in CD11c-expressing phagocytes and a later protective role for NF-\u03baB in LysM-expressing cells during Mtb infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiae060","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T22:21:26Z","timestamp":1707344486000},"page":"336-345","source":"Crossref","is-referenced-by-count":6,"title":["Nuclear Factor \u03baB Signaling Deficiency in CD11c-Expressing Phagocytes Mediates Early Inflammatory Responses and Enhances <i>Mycobacterium tuberculosis<\/i> Control"],"prefix":"10.1093","volume":"230","author":[{"given":"Kuldeep S","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Chicago , Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah D","family":"Dunlap","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University in 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Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen B","family":"Dela Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Chicago , Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-3436","authenticated-orcid":false,"given":"Makedonka","family":"Mitreva","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Washington University in St Louis, Missouri"},{"name":"McDonnell Genome Institute, Washington University in St Louis , Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabaana A","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Chicago , Illinois"},{"name":"Department of Molecular Microbiology, Washington University in St Louis, 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