{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:15Z","timestamp":1787008995670,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovative Medicines Initiatives 2 Joint Undertaking","award":["806776)"],"award-info":[{"award-number":["806776)"]}]},{"DOI":"10.13039\/501100002999","name":"Dutch Ministry of Health, Welfare and Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research innovation program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Determining pneumococcal pneumonia (PP) burden in the elderly population is challenging due to limited data on invasive PP (IPP) and, in particular, noninvasive PP (NIPP) incidence. Using retrospective cohorts of adults aged \u226550 years in Denmark (2 782 303) and the Valencia region, Spain (2 283 344), we found higher IPP hospitalization rates in Denmark than Valencia (18.3 vs 9\/100 000 person-years [PY], respectively). Conversely, NIPP hospitalization rates were higher in Valencia (48.2 vs 7.2\/100 000 PY). IPP and NIPP rates increased with age and comorbidities in both regions, with variations by sex and case characteristics (eg, complications, mortality). The burden of PP in adults is substantial, yet its true magnitude remains elusive. Discrepancies in clinical practices impede international comparisons; for instance, Valencia employed a higher frequency of urinary antigen tests compared to Denmark. Additionally, coding practices and prehospital antibiotic utilization may further influence these variations. These findings could guide policymakers and enhance the understanding of international disparities in disease burden assessments.<\/jats:p>","DOI":"10.1093\/infdis\/jiae088","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T13:51:10Z","timestamp":1708609870000},"page":"e559-e567","source":"Crossref","is-referenced-by-count":3,"title":["Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged \u226550 Years: Assessing Variability Across Denmark and Spain"],"prefix":"10.1093","volume":"230","author":[{"given":"M\u00f3nica","family":"L\u00f3pez-Lacort","sequence":"first","affiliation":[{"name":"Vaccine Research Department of Fisabio-Public Health , Valencia, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, Instituto de Salud Carlos III , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzyeh","family":"Amini","sequence":"additional","affiliation":[{"name":"P95 Epidemiology and Pharmacovigilance , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-0864","authenticated-orcid":false,"given":"Hanne-Dorthe","family":"Emborg","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-2219","authenticated-orcid":false,"given":"Jens","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A","family":"McDonald","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control, National Institute for Public Health and the Environment , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Valentiner-Branth","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"D\u00edez-Domingo","sequence":"additional","affiliation":[{"name":"Vaccine Research Department of Fisabio-Public Health , Valencia, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, Instituto de Salud Carlos III , Madrid , Spain"},{"name":"Chair of Vaccines, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-3187","authenticated-orcid":false,"given":"Alejandro","family":"Orrico-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Vaccine Research Department of Fisabio-Public Health , 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