{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:46:22Z","timestamp":1789055182807,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Nantes CHU"},{"DOI":"10.13039\/501100007601","name":"European Union\u2019s Horizon 2020 Research and Innovation Program","doi-asserted-by":"publisher","award":["847782"],"award-info":[{"award-number":["847782"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Critical illness induces immune disorders associated with an increased risk of hospital-acquired pneumonia (HAP) and acute respiratory distress syndrome (ARDS). Torque teno virus (TTV), from the Anelloviridae family, is proposed as a biomarker to measure the level of immunosuppression. Our objective was to describe the kinetics of TTV DNA loads and their association with critical illness\u2013related complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a longitudinal study in 115 patients with brain injury from a prospective cohort, collected endotracheal and blood samples at 3 successive time points after admission in the intensive care unit (ICU) (T1, 0\u20134 days post ICU admission; T2, 5\u201310; T3, 11\u201318), and measured viral DNA loads using the TTV R-GENE kit (BioM\u00e9rieux) and a pan-Anelloviridae in-house quantitative real-time polymerase chain reaction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>TTV DNA was detected in the blood of 69%, 71%, and 64% of patients with brain injury at T1, T2, and T3, respectively. Time-associated variations of TTV and anellovirus DNA loads were observed. Using a linear mixed-effects model, we found that HAP and ARDS were associated with lower blood anellovirus DNA loads.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results show that HAP or ARDS in patients who are critically ill is associated with changes in anellovirus DNA loads and should be evaluated further as a biomarker of immune disorders leading to these complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae110","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T22:38:23Z","timestamp":1709246303000},"page":"1139-1146","source":"Crossref","is-referenced-by-count":9,"title":["Association of Dynamics of Anellovirus Loads With Hospital-Acquired Pneumonia in Patients With Brain Injury During the Intensive Care Unit Stay"],"prefix":"10.1093","volume":"230","author":[{"given":"Louise","family":"Castain","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Virologie, F-44000, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Petrier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bulteau","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Peltier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Poulain","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Service d\u2019Anesth\u00e9sie R\u00e9animation , F-44000, Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Bouras","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN2, F-44000, Nantes, 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