{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:34:33Z","timestamp":1782401673447,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else-Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2021_EKEA25"],"award-info":[{"award-number":["2021_EKEA25"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the recent mpox outbreak, people with human immunodeficiency virus (PWH) were at high risk both for contracting infection and for a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PWH) or smallpox vaccination (n = 17; all PWH) in a cohort of men who have sex with men. All PWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. Eleven of 17 vaccinated individuals had received childhood smallpox vaccination. In this group of individuals, both 2-dose modified vaccinia Ankara (MVA) vaccination and natural infection evoked mpox-specific immune responses mediated by B cells as well as CD4 and CD8 T cells. This study improves our understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and long-lasting durability of childhood smallpox vaccination-mediated immune responses, including in PWH.<\/jats:p>","DOI":"10.1093\/infdis\/jiae138","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T20:13:31Z","timestamp":1710360811000},"page":"1110-1119","source":"Crossref","is-referenced-by-count":12,"title":["Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7583-6849","authenticated-orcid":false,"given":"Eva","family":"Gr\u00fcner","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Grossegesse","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses (ZBS 1) , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stern","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, Centre for Biological Threats and Special Pathogens, Biological Toxins (ZBS 3) , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Ober","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabea M","family":"Eser","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research , Munich ,","place":["Germany"]},{"name":"Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Reiling","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Stirner","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Postel","sequence":"additional","affiliation":[{"name":"Prinzmed , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Conca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr von Hauner Children's Hospital, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"D\u00e4chert","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[{"name":"Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI) , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI) , La Jolla, California ,","place":["USA"]},{"name":"Department of Pathology, University of California, San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bogner","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Seybold","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Roider","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich , Munich ,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"2024111514561354500_jiae138-B1","author":"World Health Organization"},{"key":"2024111514561354500_jiae138-B2","author":"World Health 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