{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:05:46Z","timestamp":1789589146878,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/2(19)\/CD\/2021-NCD-II"],"award-info":[{"award-number":["3\/1\/2(19)\/CD\/2021-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Grants Commission-DAE","award":["CRS\/2021\u201322\/02\/510"],"award-info":[{"award-number":["CRS\/2021\u201322\/02\/510"]}]},{"name":"Government of India","award":["BT\/INF\/22\/SP45365\/2022"],"award-info":[{"award-number":["BT\/INF\/22\/SP45365\/2022"]}]},{"name":"Government of India","award":["BT\/PR42168\/MED\/29\/1596\/2022"],"award-info":[{"award-number":["BT\/PR42168\/MED\/29\/1596\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Concerns regarding toxicity and resistance of current drugs in visceral leishmaniasis have been reported. Antimicrobial peptides are considered to be promising candidates and among them human cathelicidin hCAP18\/LL-37 showed significant parasite killing on drug-sensitive and resistant Leishmania promastigotes, in addition to its apoptosis-inducing role. Administration of hCAP18\/LL-37 to infected macrophages also decreased parasite survival and increased the host favorable cytokine interleukin 12. However, 1,25-dihydroxyvitamin D3 (vitamin D3)-induced endogenous hCAP18\/LL-37 production was hampered in infected THP-1 cells. Infection also suppressed the vitamin D3 receptor (VDR), transcription factor of hCAP18\/LL-37. cAMP response element modulator (CREM), the repressor of VDR, was induced in infection, resulting in suppression of both VDR and cathelicidin expression. PGE2\/cAMP\/PKA axis was found to regulate CREM induction during infection and silencing CREM in infected cells and BALB\/c mice led to decreased parasite survival. This study documents the antileishmanial potential of cathelicidin and further identifies CREM as a repressor of cathelicidin in Leishmania infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiae158","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T22:19:56Z","timestamp":1711577996000},"page":"172-182","source":"Crossref","is-referenced-by-count":5,"title":["Antileishmanial Activity of Cathelicidin and its Modulation by <i>Leishmania donovani<\/i> in a cAMP Response Element Modulator-Dependent Manner in Infection"],"prefix":"10.1093","volume":"230","author":[{"given":"Shalini","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Calcutta , Kolkata , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souravi","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Calcutta , Kolkata , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Calcutta , Kolkata , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Madbhagat","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Indian Institute of Science Education and Research Bhopal , Bhopal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Chande","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Indian Institute of Science Education and Research Bhopal , Bhopal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-9437","authenticated-orcid":false,"given":"Anindita","family":"Ukil","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Calcutta , Kolkata , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"2024072520111845000_jiae158-B1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.idc.2012.03.005","article-title":"Visceral leishmaniasis","volume":"26","author":"Van Griensven","year":"2012","journal-title":"Infect Dis Clin North Am"},{"key":"2024072520111845000_jiae158-B2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1186\/s13071-017-2530-9","article-title":"Variations in visceral leishmaniasis burden, mortality and the pathway to care within Bihar, India","volume":"10","author":"Jervis","year":"2017","journal-title":"Parasit Vectors"},{"key":"2024072520111845000_jiae158-B3","doi-asserted-by":"crossref","first-page":"9872095","DOI":"10.1155\/2018\/9872095","article-title":"Current visceral leishmaniasis research: a research review to inspire future study","volume":"2018","author":"Bi","year":"2018","journal-title":"BioMed Res Int"},{"key":"2024072520111845000_jiae158-B4","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"WHO leishmaniasis control team. 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