{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:47Z","timestamp":1753877087627,"version":"3.41.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI150797","R21AI146397"],"award-info":[{"award-number":["R01AI150797","R21AI146397"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Missouri Metabolomics Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The impact of vaccine-induced immune responses on host metabolite availability has not been well studied. Here we show that prior vaccination alters the metabolic profile of mice challenged with Brucella melitensis. In particular, glucose levels were reduced in vaccinated mice in an antibody-dependent manner. We also found the glucose transporter gene gluP plays a lesser role in B melitensis virulence in vaccinated wild type mice relative to vaccinated mice unable to secrete antibodies. These data indicate that vaccine-elicited antibodies protect the host in part by restricting glucose availability. Moreover, Brucella and other pathogens may need to employ different metabolic strategies in vaccinated hosts.<\/jats:p>","DOI":"10.1093\/infdis\/jiae172","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:29:15Z","timestamp":1712564955000},"source":"Crossref","is-referenced-by-count":2,"title":["Vaccine-Elicited Antibodies Restrict Glucose Availability to Control <i>Brucella<\/i> Infection"],"prefix":"10.1093","author":[{"given":"B\u00e1rbara","family":"Ponzilacqua-Silva","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine"},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis S","family":"Dadelahi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine"},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-3800","authenticated-orcid":false,"given":"Mostafa F N","family":"Abushahba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine"},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia"},{"name":"Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R","family":"Moley","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine"},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-908X","authenticated-orcid":false,"given":"Jerod A","family":"Skyberg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine"},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"2024042617462470800_jiae172-B1","first-page":"e06406","article-title":"The European Union one health 2019 zoonoses report","volume":"19","author":"European Food Safety Authority and European Centre for Disease Prevention and Control","year":"2021","journal-title":"EFSA J"},{"key":"2024042617462470800_jiae172-B2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"Corbel","year":"1997","journal-title":"Emerg Infect 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