{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:24:24Z","timestamp":1790223864287,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The extent to which infections may have been undetected in an epicenter of the 2022 mpox outbreak is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A serosurvey (July and August 2022) assessed the seroprevalence and correlates of mpox infection among a diverse sample of asymptomatic patients with no prior mpox diagnoses and no known histories of smallpox or mpox vaccination. We present seropositivity stratified by participant characteristics collected via survey.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two-thirds of 419 participants were cismen (281 of 419), of whom 59.1% (166 of 281) reported sex with men (MSM). The sample also included 109 ciswomen and 28 transgender\/gender nonconforming\/nonbinary individuals. Overall seroprevalence was 6.4% (95% confidence interval [CI], 4.1%\u20138.8%); 3.7% among ciswomen (95% CI, 1.0%\u20139.1%), 7.0% among cismen with only ciswomen partners (95% CI, 2.0%\u201311.9%), and 7.8% among MSM (95% CI, 3.7%\u201311.9%). There was little variation in seroprevalence by race\/ethnicity, age group, HIV status, or number of recent sex partners. No participants who reported close contact with mpox cases were seropositive. Among participants without recent mpox-like symptoms, 6.3% were seropositive (95% CI, 3.6%\u20139.0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Approximately 1 in 15 vaccine-naive people in our study had antibodies to mpox during the height of the NYC outbreak, indicating the presence of asymptomatic infections that could contribute to ongoing transmission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae181","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:44:22Z","timestamp":1715579062000},"page":"1102-1109","source":"Crossref","is-referenced-by-count":12,"title":["Serological Evidence of Mpox Virus Infection During Peak Mpox Transmission in New York City, July to August 2022"],"prefix":"10.1093","volume":"230","author":[{"given":"Preeti","family":"Pathela","sequence":"first","affiliation":[{"name":"Bureau of Hepatitis, HIV, and STI, New York City Department of Health and Mental Hygiene , Queens, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Townsend","sequence":"additional","affiliation":[{"name":"Multinational Mpox Response, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik J","family":"Kopping","sequence":"additional","affiliation":[{"name":"Bureau of the Public Health Laboratory, New York City Department of Health and Mental Hygiene , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tang","sequence":"additional","affiliation":[{"name":"Bureau of Hepatitis, HIV, and STI, New York City Department of Health and Mental Hygiene , Queens, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terese","family":"Navarra","sequence":"additional","affiliation":[{"name":"Multinational Mpox Response, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Priyamvada","sequence":"additional","affiliation":[{"name":"Multinational Mpox Response, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Carson","sequence":"additional","affiliation":[{"name":"Multinational Mpox Response, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Satheshkumar","family":"Panayampalli","sequence":"additional","affiliation":[{"name":"Multinational Mpox Response, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal C","family":"Fowler","sequence":"additional","affiliation":[{"name":"Bureau of the Public Health Laboratory, New York City Department of Health and Mental Hygiene , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nang","family":"Kyaw","sequence":"additional","affiliation":[{"name":"Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]},{"name":"Bureau of Healthcare and Community Readiness, New York City Department of Health and Mental Hygiene , Queens, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hughes","sequence":"additional","affiliation":[{"name":"Bureau of the Public Health Laboratory, New York City Department of Health and Mental Hygiene , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Jamison","sequence":"additional","affiliation":[{"name":"Bureau of Hepatitis, HIV, and STI, New York City Department of Health and Mental Hygiene , Queens, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024111514523601600_jiae181-B1"},{"key":"2024111514523601600_jiae181-B2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox virus infection in humans across 16 countries\u2014April\u2013June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N Engl J Med"},{"key":"2024111514523601600_jiae181-B3","author":"Centers for Disease Control and Prevention"},{"key":"2024111514523601600_jiae181-B4","first-page":"867","article-title":"Characterization of acute-phase humoral immunity to monkeypox: use of immunoglobulin M enzyme-linked immunosorbent assay for detection of monkeypox infection during the 2003 North American outbreak","volume":"12","author":"Karem","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"2024111514523601600_jiae181-B5","doi-asserted-by":"crossref","first-page":"e28851","DOI":"10.1002\/jmv.28851","article-title":"Profiling the acute phase antibody response against mpox virus in patients infected during the 2022 outbreak","volume":"95","author":"Colavita","year":"2023","journal-title":"J Med Virol"},{"key":"2024111514523601600_jiae181-B6","doi-asserted-by":"crossref","first-page":"106102","DOI":"10.1016\/j.isci.2023.106102","article-title":"Kinetics of viral DNA in body fluids and antibody response in patients with acute monkeypox virus infection","volume":"26","author":"Colavita","year":"2023","journal-title":"iScience"},{"key":"2024111514523601600_jiae181-B7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.15585\/mmwr.mm7122e1","article-title":"Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2022","volume":"71","author":"Rao","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.chom.2023.05.001","article-title":"Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals","volume":"31","author":"Hubert","year":"2023","journal-title":"Cell Host Microbe"},{"key":"2024111514523601600_jiae181-B9","volume-title":"Monographs in virology","author":"Jezek","year":"1988"},{"key":"2024111514523601600_jiae181-B10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/cid\/ciad145","article-title":"Evidence of mpox virus infection among persons without characteristic lesions or rash presenting for first dose of JYNNEOS vaccine\u2014District of Columbia, August 2022","volume":"77","author":"Ogale","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2024111514523601600_jiae181-B11","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.3201\/eid2911.230940","article-title":"Prevalence of undiagnosed monkeypox virus infections during global mpox outbreak, United States, June-September 2022","volume":"29","author":"Minhaj","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"2024111514523601600_jiae181-B12","author":"New York City Department of Health and Mental Hygiene"},{"key":"2024111514523601600_jiae181-B13","first-page":"867","article-title":"Characterization of acute-phase humoral immunity to monkeypox: use of immunoglobulin M enzyme-linked immunosorbent assay for detection of monkeypox infection during the 2003 North American outbreak","volume":"12","author":"Karem","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"2024111514523601600_jiae181-B14","doi-asserted-by":"crossref","first-page":"2200869","DOI":"10.2807\/1560-7917.ES.2023.28.17.2200869","article-title":"Mpox outbreak among men who have sex with men in Amsterdam and Rotterdam, The Netherlands: no evidence for undetected transmission prior to May 2022, a retrospective study","volume":"28","author":"de Vries","year":"2023","journal-title":"Euro Surveill"},{"key":"2024111514523601600_jiae181-B15","author":"Koppe"},{"key":"2024111514523601600_jiae181-B16","author":"Golden"},{"key":"2024111514523601600_jiae181-B17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.15585\/mmwr.mm7132e3","article-title":"Epidemiologic and clinical characteristics of monkeypox cases\u2014United States, May 17\u2013July 22, 2022","volume":"71","author":"Philpott","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.15585\/mmwr.mm7213a4","article-title":"JYNNEOS vaccination coverage among persons at risk for mpox\u2014United States, May 22, 2022\u2013January 31, 2023","volume":"72","author":"Owens","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B19","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.15585\/mmwr.mm7149a5","article-title":"Reduced risk for mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons\u201443 U.S. jurisdictions, July 31\u2013October 1, 2022","volume":"71","author":"Payne","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.15585\/mmwr.mm7220a3","article-title":"Estimated effectiveness of JYNNEOS vaccine in preventing mpox: a multijurisdictional case-control study\u2014United States, August 19, 2022\u2013March 31, 2023","volume":"72","author":"Dalton","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.15585\/mmwr.mm7220a4","article-title":"Effectiveness of JYNNEOS vaccine against diagnosed mpox infection\u2014New York, 2022","volume":"72","author":"Rosenberg","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024111514523601600_jiae181-B22","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1056\/NEJMoa2215201","article-title":"Vaccine effectiveness of JYNNEOS against mpox disease in the United States","volume":"388","author":"Deputy","year":"2023","journal-title":"N Engl J Med"},{"key":"2024111514523601600_jiae181-B23","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1016\/j.vaccine.2022.10.078","article-title":"Serological responses to the MVA-based JYNNEOS monkeypox vaccine in a cohort of participants from the Democratic Republic of Congo","volume":"40","author":"Priyamvada","year":"2022","journal-title":"Vaccine"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae181\/57567704\/jiae181.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/5\/1102\/60683722\/jiae181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/5\/1102\/60683722\/jiae181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T14:52:47Z","timestamp":1731682367000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/230\/5\/1102\/7670756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae181","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11,15]]},"published":{"date-parts":[[2024,5,13]]}}}