{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:27:01Z","timestamp":1779114421374,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated long-term trajectories of circulating hepatitis B virus (HBV) RNA and hepatitis B core\u2013related antigen (HBcrAg) in persons with and without hepatitis B surface antigen (HBsAg) loss during tenofovir therapy in the Swiss HIV Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 29 persons with HIV with HBsAg loss and 29 matched persons with HIV without HBsAg loss. We compared HBV RNA and HBcrAg decline and assessed the cumulative proportions with undetectable HBV RNA and HBcrAg levels during tenofovir therapy using Kaplan-Meier estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HBsAg loss occurred after a median of 4 years (IQR, 1\u20138). All participants with HBsAg loss achieved suppressed HBV DNA and undetectable HBV RNA preceding undetectable quantitative HBsAg levels, whereas 79% achieved negative HBcrAg. In comparison, 79% of participants without HBsAg loss achieved undetectable HBV-RNA and 48% negative HBcrAg. After 2 years of tenofovir therapy, an HBV RNA decline \u22651 log10 copies\/mL had 100% sensitivity and 36.4% specificity for HBsAg loss, whereas an HBcrAg decline \u22651 log10 U\/mL had 91.0% sensitivity and 64.5% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HBV RNA suppression preceded undetectable quantitative HBsAg levels and had high sensitivity but low specificity for HBsAg loss during tenofovir therapy in persons with HIV. HBcrAg remained detectable in approximately 20% of persons with HBsAg loss and 50% of persons without HBsAg loss.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiae189","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T19:49:23Z","timestamp":1713296963000},"source":"Crossref","is-referenced-by-count":1,"title":["Circulating HBV RNA and Hepatitis B Core\u2013Related Antigen Trajectories in Persons With HIV\/HBV Coinfection and Hepatitis B Surface Antigen Loss During Tenofovir Therapy"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-8947","authenticated-orcid":false,"given":"Lorin","family":"Begr\u00e9","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Switzerland"},{"name":"Graduate School for Health Sciences, University of Bern , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-8928","authenticated-orcid":false,"given":"Anders","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention, Public Health Service of Amsterdam , The Netherlands"},{"name":"Stichting hiv monitoring Amsterdam , The Netherlands"},{"name":"Department ofInfectious Diseases, Amsterdam UMC location University of Amsterdam , The Netherlands"},{"name":"Department ofInfectious Diseases, Amsterdam Institute for Infection and Immunity , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-4586","authenticated-orcid":false,"given":"Marie-Laure","family":"Plissonnier","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Lyon (CRCL), UMR Inserm U1052 \/ CNRS 5286 , Lyon , France"},{"name":"IHU Lyon, Lyon Hepatology Institute , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-5465","authenticated-orcid":false,"given":"Barbara","family":"Testoni","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Lyon (CRCL), UMR Inserm U1052 \/ CNRS 5286 , Lyon , France"},{"name":"IHU Lyon, Lyon Hepatology Institute , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-0141","authenticated-orcid":false,"given":"Luisa","family":"Salazar-Vizcaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-578X","authenticated-orcid":false,"given":"Franziska","family":"Suter-Riniker","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases, University of Bern , 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