{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:07:23Z","timestamp":1784603243567,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Powassan virus is a tick-borne flavivirus that can cause severe neuroinvasive disease, with areas of endemicity in the Northeast and Midwest United States, Canada, and Russia. Diagnosis is challenging and relies on a high index of suspicion and choosing the right test based on duration of infection and the patient's immune status. This review covers laboratory testing for Powassan virus, including historical considerations, modern options, and methods being developed in the research space.<\/jats:p>","DOI":"10.1093\/infdis\/jiae197","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:47:14Z","timestamp":1723636034000},"page":"S70-S75","source":"Crossref","is-referenced-by-count":11,"title":["Laboratory Testing for Powassan Virus: Past, Present, and Future"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-972X","authenticated-orcid":false,"given":"Erik H","family":"Klontz","sequence":"first","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital , Boston, Massachusetts , USA"},{"name":"Department of Pathology, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Branda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital , Boston, Massachusetts , USA"},{"name":"Department of Pathology, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"2024081411465500700_jiae197-B1","first-page":"708","article-title":"Powassan virus: isolation of virus from a fatal case of encephalitis","volume":"80","author":"McLean","year":"1959","journal-title":"Can Med Assoc 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