{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:28:32Z","timestamp":1793320112371,"version":"4.5.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI161019"],"award-info":[{"award-number":["R01AI161019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chlamydia trachomatis (CT) is a sexually transmitted infection that can lead to adverse reproductive health outcomes. CT prevalence estimates are primarily derived from screening using nucleic acid amplification tests (NAATs). However, screening guidelines in the United States only include particular subpopulations, and NAATs only detect current infections. In contrast, seroassays identify past CT infections, which is important for understanding the public health impacts of CT, including pelvic inflammatory disease and tubal factor infertility. Older seroassays have been plagued by low sensitivity and specificity and have not been validated using a consistent reference measure, making it challenging to compare studies, define the epidemiology of CT, and determine the effectiveness of control programs. Newer seroassays have better performance characteristics. This narrative review summarizes the \u201cstate of the science\u201d for CT seroassays that have been applied in epidemiologic studies and provides practical considerations for interpreting the literature and employing seroassays in future research.<\/jats:p>","DOI":"10.1093\/infdis\/jiae199","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T21:05:20Z","timestamp":1713301520000},"page":"250-262","source":"Crossref","is-referenced-by-count":9,"title":["<i>Chlamydia trachomatis<\/i>\n                    Seroassays Used in Epidemiologic Research: A Narrative Review and Practical Considerations"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-5443","authenticated-orcid":false,"given":"Mary Bridget","family":"Waters","sequence":"first","affiliation":[{"name":"Department of Epidemiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-3079","authenticated-orcid":false,"given":"Kevin","family":"Hybiske","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kaltenboeck","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University , Auburn, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-7654","authenticated-orcid":false,"given":"Lisa E","family":"Manhart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-9960","authenticated-orcid":false,"given":"Kristen M","family":"Kreisel","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-0829","authenticated-orcid":false,"given":"Christine M","family":"Khosropour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"2024072520125678400_jiae199-B1","author":"Centers for Disease Control and Prevention"},{"key":"2024072520125678400_jiae199-B2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/OLQ.0000000000001382","article-title":"Estimates of the prevalence and incidence of chlamydia and gonorrhea among US men and women, 2018","volume":"48","author":"Kreisel","year":"2021","journal-title":"Sex Transm Dis"},{"key":"2024072520125678400_jiae199-B3","author":"Centers for Disease Control and Prevention"},{"key":"2024072520125678400_jiae199-B4","author":"Centers for Disease Control and Prevention"},{"key":"2024072520125678400_jiae199-B5","volume-title":"Chlamydia infections in women. 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