{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:52:10Z","timestamp":1780397530706,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1019093"],"award-info":[{"award-number":["OPP1019093"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1197861"],"award-info":[{"award-number":["OPP1197861"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Quantitative molecular assays are increasingly used for detection of enteric viruses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared the clinical severity using the modified Vesikari score (mVS) of enteric viruses detected by conventional assays (enzyme immunoassays [EIAs] for rotavirus and adenovirus 40\/41 and conventional polymerase chain reaction for astrovirus, sapovirus, and norovirus) and a quantitative molecular assay (TaqMan Array Card [TAC]) among children aged 0\u201359 months in the Global Enteric Multicenter Study. For rotavirus and adenovirus 40\/41, we compared severity between EIA-positive and TAC-positive cases assigned etiologies using different cycle threshold (Ct) cutoffs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using conventional assays, the median mVS (interquartile range) was 10 (8\u201311) for rotavirus, 9 (7\u201311) for adenovirus 40\/41, 8 (6\u201310) for astrovirus, sapovirus, and norovirus GII, and 7 (6\u20139) for norovirus GI. Compared with rotavirus EIA-positive cases, the median mVS was 2 and 3 points lower for EIA-negative\/TAC-positive cases with Ct &amp;lt;32.6 or Ct \u226532.6 and &amp;lt;35, respectively (P &amp;lt; .001). Adenovirus 40\/41 EIA-positive and EIA-negative\/TAC-positive cases were similar, regardless of Ct cutoff.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Quantitative molecular assays compared with conventional assays, such as EIA, may influence the severity of identified cases, especially for rotavirus. Cutoffs to assign etiology for quantitative assays should be considered in the design and interpretation of enteric virus studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae201","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T20:50:56Z","timestamp":1713473456000},"page":"1157-1166","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Severity of Enteric Viruses Detected Using a Quantitative Molecular Assay Compared With Conventional Assays in the Global Enteric Multicenter Study"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-7416","authenticated-orcid":false,"given":"Jordan","family":"Cates","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Powell","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Platts-Mills","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health, University of Virginia , Charlottesville, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilruba","family":"Nasrin","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Panchalingam","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba O","family":"Sow","sequence":"additional","affiliation":[{"name":"Centre pour le D\u00e9veloppement des Vaccins , Bamako ,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awa","family":"Traore","sequence":"additional","affiliation":[{"name":"Centre pour le D\u00e9veloppement des Vaccins , Bamako ,","place":["Mali"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Sur","sequence":"additional","affiliation":[{"name":"National Institute of Cholera and Enteric Diseases , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thandavarayan","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"National Institute of Cholera and Enteric Diseases , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita K M","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furqan","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu S G","family":"Faruque","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research , Dhaka ,","place":["Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilruba","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research , Dhaka ,","place":["Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Breiman","sequence":"additional","affiliation":[{"name":"Department of Global Health, Rollins School of Public Health, Emory University , Atlanta, Georgia ,","place":["USA"]},{"name":"Infectious Diseases and Oncology Research Institute, University of the Witwatersrand , Johannesburg ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Omore","sequence":"additional","affiliation":[{"name":"Centers for Global Health Research (KEMRI-CGHR), Kenya Medical Research Institute , Kisumu ,","place":["Kenya"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Benjamin","family":"Ochieng","sequence":"additional","affiliation":[{"name":"Centers for Global Health Research (KEMRI-CGHR), Kenya Medical Research Institute , Kisumu ,","place":["Kenya"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Jahangir","family":"Hossain","sequence":"additional","affiliation":[{"name":"Medical Research Council (UK) Unit The Gambia at the London School of Hygiene and Tropical Medicine , Fajara ,","place":["The Gambia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Antonio","sequence":"additional","affiliation":[{"name":"Medical Research Council (UK) Unit The Gambia at the London School of Hygiene and Tropical Medicine , Fajara ,","place":["The Gambia"]},{"name":"Centre for Epidemic Preparedness and Response, London School of Hygiene & Tropical Medicine , London ,","place":["United Kingdom"]},{"name":"Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e1cio","family":"Mandomando","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a , Maputo ,","place":["Mozambique"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfino","family":"Vubil","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a , Maputo ,","place":["Mozambique"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Nataro","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Pediatrics, University of Virginia School of Medicine , Charlottesville, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-5040","authenticated-orcid":false,"given":"Myron M","family":"Levine","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh D","family":"Parashar","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Kotloff","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Medicine, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline E","family":"Tate","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"2024111514533414400_jiae201-B1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S1473-3099(18)30362-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the global burden of disease study 2016","volume":"18","author":"GBD 2016 Diarrhoeal Disease Collaborators","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2024111514533414400_jiae201-B2","doi-asserted-by":"crossref","first-page":"e1309","DOI":"10.1016\/S2214-109X(18)30349-8","article-title":"Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study","volume":"6","author":"Platts-Mills","year":"2018","journal-title":"Lancet Glob Health"},{"key":"2024111514533414400_jiae201-B3","doi-asserted-by":"crossref","first-page":"e009548","DOI":"10.1136\/bmjgh-2022-009548","article-title":"Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the global pediatric diarrhea surveillance network","volume":"7","author":"Cohen","year":"2022","journal-title":"BMJ Glob Health"},{"key":"2024111514533414400_jiae201-B4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"issue":"Suppl 2","key":"2024111514533414400_jiae201-B5","doi-asserted-by":"crossref","first-page":"S288","DOI":"10.1086\/315590","article-title":"Human caliciviruses in acute gastroenteritis of young children in the community","volume":"181","author":"Pang","year":"2000","journal-title":"J Infect Dis"},{"key":"2024111514533414400_jiae201-B6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1086\/341408","article-title":"Natural history of human calicivirus infection: a prospective cohort study","volume":"35","author":"Rockx","year":"2002","journal-title":"Clin Infect Dis"},{"key":"2024111514533414400_jiae201-B7","doi-asserted-by":"crossref","first-page":"ofac241","DOI":"10.1093\/ofid\/ofac241","article-title":"Burden, clinical characteristics, risk factors, and seasonality of adenovirus 40\/41 diarrhea in children in eight low-resource settings","volume":"9","author":"Guga","year":"2022","journal-title":"Open Forum Infect Dis"},{"issue":"Suppl 1","key":"2024111514533414400_jiae201-B8","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1093\/cid\/ciad060","article-title":"Prevalence, clinical severity, and seasonality of adenovirus 40\/41, astrovirus, sapovirus, and rotavirus among young children with moderate-to-severe diarrhea: results from the Vaccine Impact on Diarrhea in Africa (VIDA) study","volume":"76","author":"Keita","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2024111514533414400_jiae201-B9","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s10096-014-2135-6","article-title":"Diagnosis of viral gastroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms","volume":"33","author":"Corcoran","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2024111514533414400_jiae201-B10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/INF.0000000000001824","article-title":"Norovirus and rotavirus disease severity in children: systematic review and meta-analysis","volume":"37","author":"Riera-Montes","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"2024111514533414400_jiae201-B11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0140-6736(16)31529-X","article-title":"Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"2024111514533414400_jiae201-B12","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1016\/j.vaccine.2020.01.054","article-title":"Meeting report: WHO workshop on modelling global mortality and aetiology estimates of enteric pathogens in children under five. Cape Town, 28\u201329th November 2018","volume":"38","author":"Prudden","year":"2020","journal-title":"Vaccine"},{"issue":"Suppl 4","key":"2024111514533414400_jiae201-B13","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1093\/cid\/cis753","article-title":"The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case\/control study","volume":"55","author":"Kotloff","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"Suppl 4","key":"2024111514533414400_jiae201-B14","doi-asserted-by":"crossref","first-page":"S294","DOI":"10.1093\/cid\/cis754","article-title":"Diagnostic microbiologic methods in the GEMS-1 case\/control study","volume":"55","author":"Panchalingam","year":"2012","journal-title":"Clin Infect Dis"},{"key":"2024111514533414400_jiae201-B15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1473-3099(14)70808-4","article-title":"Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study","volume":"14","author":"Liu","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"2024111514533414400_jiae201-B16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/00365549009027046","article-title":"Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes","volume":"22","author":"Ruuska","year":"1990","journal-title":"Scand J Infect Dis"},{"key":"2024111514533414400_jiae201-B17","doi-asserted-by":"crossref","first-page":"e0160060","DOI":"10.1371\/journal.pone.0160060","article-title":"Epidemiology, seasonality and factors associated with rotavirus infection among children with moderate-to-severe diarrhea in rural western Kenya, 2008\u20132012: the Global Enteric Multicenter Study (GEMS)","volume":"11","author":"Omore","year":"2016","journal-title":"PLoS One"},{"key":"2024111514533414400_jiae201-B18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/14712598.2021.1977279","article-title":"Rotavirus vaccines: progress and new developments","volume":"22","author":"Cates","year":"2022","journal-title":"Expert Opin Biol Ther"},{"key":"2024111514533414400_jiae201-B19","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/infdis\/jiaa081","article-title":"Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children &lt;5 years old: 2006\u20132019","volume":"222","author":"Burnett","year":"2020","journal-title":"J Infect Dis"},{"key":"2024111514533414400_jiae201-B20","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/infdis\/jiaa086","article-title":"Winning the battle against rotavirus diarrhea\u2026one step at a time","volume":"222","author":"Groome","year":"2020","journal-title":"J Infect Dis"},{"key":"2024111514533414400_jiae201-B21","doi-asserted-by":"crossref","first-page":"e1195","DOI":"10.1016\/S2214-109X(20)30262-X","article-title":"Real-world effectiveness of rotavirus vaccines, 2006\u201319: a literature review and meta-analysis","volume":"8","author":"Burnett","year":"2020","journal-title":"Lancet Glob Health"},{"key":"2024111514533414400_jiae201-B22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/jmv.20053","article-title":"Quantitation of group A rotavirus by real-time reverse-transcription-polymerase chain reaction: correlation with clinical severity in children in south India","volume":"73","author":"Kang","year":"2004","journal-title":"J Med Virol"},{"key":"2024111514533414400_jiae201-B23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jcv.2009.11.012","article-title":"Viral load and genotypes of noroviruses in symptomatic and asymptomatic children in southeastern Brazil","volume":"47","author":"Barreira","year":"2010","journal-title":"J Clin Virol"},{"key":"2024111514533414400_jiae201-B24","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/jmv.22185","article-title":"Molecular epidemiology of enteric viruses in children with sporadic gastroenteritis in Valencia, Venezuela","volume":"83","author":"Gonz\u00e1lez","year":"2011","journal-title":"J Med Virol"},{"key":"2024111514533414400_jiae201-B25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/infdis\/jix294","article-title":"Etiology of severe acute watery diarrhea in children in the Global Rotavirus Surveillance Network using quantitative polymerase chain reaction","volume":"216","author":"Operario","year":"2017","journal-title":"J Infect Dis"},{"key":"2024111514533414400_jiae201-B26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1473-3099(14)70767-4","article-title":"Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis","volume":"14","author":"Ahmed","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"2024111514533414400_jiae201-B27","doi-asserted-by":"crossref","first-page":"905172","DOI":"10.3389\/fpubh.2022.905172","article-title":"Global burden and trends of norovirus-associated diseases from 1990 to 2019: an observational trend study","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Public Health"},{"issue":"Suppl 1","key":"2024111514533414400_jiae201-B28","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1093\/cid\/ciac967","article-title":"Norovirus disease among children &lt;5 years in 3 sub-Saharan African countries: findings from the Vaccine Impact on Diarrhea in Africa (VIDA) study, 2015\u20132018","volume":"76","author":"Omore","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2024111514533414400_jiae201-B29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/14760584.2020.1777860","article-title":"Recent advances in human norovirus research and implications for candidate vaccines","volume":"19","author":"Cates","year":"2020","journal-title":"Expert Rev Vaccines"},{"key":"2024111514533414400_jiae201-B30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/CMR.00011-14","article-title":"Comprehensive review of human sapoviruses","volume":"28","author":"Oka","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"2024111514533414400_jiae201-B31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cid\/civ873","article-title":"Host genetic susceptibility to enteric viruses: a systematic review and metaanalysis","volume":"62","author":"Kambhampati","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024111514533414400_jiae201-B32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/0470846534.ch2","article-title":"Gastroenteritis viruses: an overview","volume":"238","author":"Glass","year":"2001","journal-title":"Novartis Found Symp"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae201\/58202698\/jiae201.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/5\/1157\/60683804\/jiae201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/5\/1157\/60683804\/jiae201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T14:53:51Z","timestamp":1731682431000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/230\/5\/1157\/7651179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,4,18]]},"published-print":{"date-parts":[[2024,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae201","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11,15]]},"published":{"date-parts":[[2024,4,18]]}}}