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Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P &amp;lt; .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P &amp;lt; .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.<\/jats:p>","DOI":"10.1093\/infdis\/jiae208","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T11:07:50Z","timestamp":1714734470000},"page":"689-695","source":"Crossref","is-referenced-by-count":1,"title":["Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum"],"prefix":"10.1093","volume":"230","author":[{"given":"Linxuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle"},{"name":"Department of Global Health, University of Washington , Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kinuthia","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle"},{"name":"Department of Research and Programs, Kenyatta National Hospital , Nairobi , Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado , Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared M","family":"Baeten","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle"},{"name":"Department of Global Health, University of Washington , Seattle"},{"name":"Department of Medicine, University of Washington , Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia C","family":"Dettinger","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-1994","authenticated-orcid":false,"given":"Monica","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laur\u00e9n","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle"},{"name":"Department of Global Health, University of Washington , Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-1573","authenticated-orcid":false,"given":"Grace","family":"John-Stewart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle"},{"name":"Department of Global Health, University of Washington , Seattle"},{"name":"Department of Medicine, University of Washington , Seattle"},{"name":"Department of Pediatrics, School of Medicine, University of Washington, Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M","family":"Marwa","sequence":"additional","affiliation":[{"name":"Department of Research and Programs, Kenyatta National Hospital , Nairobi , Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Ngumbau","sequence":"additional","affiliation":[{"name":"Department of Research and Programs, Kenyatta National Hospital , Nairobi , Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Otieno","sequence":"additional","affiliation":[{"name":"Department of Research and Programs, Kenyatta National Hospital , Nairobi , Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Omondi","sequence":"additional","affiliation":[{"name":"Department of Research and Programs, Kenyatta National 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Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"2024092316164068400_jiae208-B1","volume-title":"WHO technical brief: preventing HIV during pregnancy and breastfeeding in the context of pre-exposure prophylaxis (PrEP).","author":"World Health Organization","year":"2017"},{"key":"2024092316164068400_jiae208-B2","doi-asserted-by":"crossref","first-page":"F13","DOI":"10.1097\/QAD.0b013e3283522272","article-title":"Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention","volume":"26","author":"van der Straten","year":"2012","journal-title":"AIDS"},{"key":"2024092316164068400_jiae208-B3","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1097\/QAD.0000000000003617","article-title":"PrEP initiation, persistence, and adherence during pregnancy through the postpartum period: a prospective analysis in 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