{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:10:51Z","timestamp":1790698251479,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"DOI":"10.1093\/infdis\/jiae246","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T23:56:01Z","timestamp":1723766161000},"page":"275-277","source":"Crossref","is-referenced-by-count":1,"title":["T-Cell Responses to <i>Treponema pallidum<\/i> Proteins in Blood and Skin to Advance Syphilis Vaccine Design: Learning From Nature"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-546X","authenticated-orcid":false,"given":"Juan C","family":"Salazar","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Immunology, University of Connecticut School of Medicine , Farmington"},{"name":"Division of Pediatric Infectious Diseases and Immunology, Connecticut Children's , Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D","family":"Radolf","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Immunology, University of Connecticut School of Medicine , Farmington"},{"name":"Departments of 4 Medicine"},{"name":"Genetics and Genome Sciences"},{"name":"Molecular Biology and Biophysics, University of Connecticut School of Medicine , Farmington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"2024081523535180100_jiae246-B1","first-page":"2865","volume-title":"Mandell, Douglas and Bennett's principles and practice of infectious diseases","author":"Radolf","year":"2019","edition":"9th ed"},{"key":"2024081523535180100_jiae246-B2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0140-6736(22)02348-0","article-title":"Syphilis","volume":"402","author":"Peeling","year":"2023","journal-title":"Lancet"},{"key":"2024081523535180100_jiae246-B3","doi-asserted-by":"crossref","first-page":"e1001396","DOI":"10.1371\/journal.pmed.1001396","article-title":"Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data","volume":"10","author":"Newman","year":"2013","journal-title":"PLoS Med"},{"key":"2024081523535180100_jiae246-B4","author":"Centers for Disease Control and Prevention"},{"key":"2024081523535180100_jiae246-B5","first-page":"1","article-title":"The Treponema pallidum outer membrane","volume":"415","author":"Radolf","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"2024081523535180100_jiae246-B6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","article-title":"Biological basis for syphilis","volume":"19","author":"Lafond","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"2024081523535180100_jiae246-B7","doi-asserted-by":"crossref","first-page":"e0008221","DOI":"10.1128\/JB.00082-21","article-title":"Structural modeling of the Treponema pallidum OMPeome: a roadmap for deconvolution of syphilis pathogenesis and development of a syphilis vaccine","volume":"203","author":"Hawley","year":"2021","journal-title":"J Bacteriol"},{"key":"2024081523535180100_jiae246-B8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/OLQ.0b013e318162c4f2","article-title":"Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture","volume":"35","author":"Lukehart","year":"2008","journal-title":"Sex Transm Dis"},{"key":"2024081523535180100_jiae246-B9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3389\/fimmu.2017.01227","article-title":"IFN\u03b3 enhances CD64-potentiated phagocytosis of Treponema pallidum opsonized with human syphilitic serum by human macrophages","volume":"8","author":"Hawley","year":"2017","journal-title":"Front Immunol"},{"key":"2024081523535180100_jiae246-B10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1128\/JCM.44.3.888-891.2006","article-title":"Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome","volume":"44","author":"Brinkman","year":"2006","journal-title":"J Clin Microbiol"},{"key":"2024081523535180100_jiae246-B11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1086\/511822","article-title":"Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis","volume":"195","author":"Salazar","year":"2007","journal-title":"J Infect Dis"},{"key":"2024081523535180100_jiae246-B12","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1128\/JB.00086-15","article-title":"A homology model reveals novel structural features and an immunodominant surface loop\/opsonic target in the Treponema pallidum BamA ortholog TP_0326","volume":"197","author":"Luthra","year":"2015","journal-title":"J Bacteriol"},{"key":"2024081523535180100_jiae246-B13","doi-asserted-by":"crossref","first-page":"e0163922","DOI":"10.1128\/mbio.01639-22","article-title":"Extracellular loops of the Treponema pallidum FadL orthologs TP0856 and TP0858 elicit IgG antibodies and IgG(+)-specific B-cells in the rabbit model of experimental syphilis","volume":"13","author":"Delgado","year":"2022","journal-title":"mBio"},{"key":"2024081523535180100_jiae246-B14","doi-asserted-by":"crossref","first-page":"1222267","DOI":"10.3389\/fimmu.2023.1222267","article-title":"Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)","volume":"14","author":"Ferguson","year":"2023","journal-title":"Front Immunol"},{"key":"2024081523535180100_jiae246-B15","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1128\/IAI.67.9.4757-4763.1999","article-title":"T-cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection","volume":"67","author":"Arroll","year":"1999","journal-title":"Infect Immun"},{"key":"2024081523535180100_jiae246-B16","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1128\/iai.58.9.3158-3161.1990","article-title":"Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis","volume":"58","author":"Champion","year":"1990","journal-title":"Infect Immun"},{"key":"2024081523535180100_jiae246-B17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acs.jproteome.3c00891","article-title":"In-depth proteome coverage of in vitro-cultured Treponema pallidum and quantitative comparison analyses with in vivo\u2013grown treponemes","volume":"23","author":"Houston","year":"2024","journal-title":"J Proteome Res"},{"key":"2024081523535180100_jiae246-B18","doi-asserted-by":"crossref","first-page":"e1717","DOI":"10.1371\/journal.pntd.0001717","article-title":"Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments","volume":"6","author":"Cruz","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"2024081523535180100_jiae246-B19","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2353\/ajpath.2010.100277","article-title":"Host defense mechanisms in secondary syphilitic lesions: a role for IFN\u03b3\/IL-17-producing CD8+ T cells?","volume":"177","author":"Stary","year":"2010","journal-title":"Am J Pathol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/2\/275\/58809464\/jiae246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/2\/275\/58809464\/jiae246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T23:56:11Z","timestamp":1723766171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/230\/2\/275\/7699963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,27]]},"published-print":{"date-parts":[[2024,8,16]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae246","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8,15]]},"published":{"date-parts":[[2024,6,27]]}}}