{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:24:28Z","timestamp":1791228268343,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Harold W. Jockers Professorship"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lyme disease is a zoonotic infection due to Ixodes tick\u2013transmitted Borrelia burgdorferi sensu lato spirochetes and the most common vector-borne disease in the Northern Hemisphere. Despite nearly 50 years of investigation, the pathogenesis of this infection and its 2 main adverse outcomes\u2014postinfectious Lyme arthritis and posttreatment Lyme disease syndrome\u2014are incompletely understood. Advancement in sequencing and mass spectrometry have led to the rapid expansion of high-throughput omics technologies, including transcriptomics, metabolomics, and proteomics, which are now being applied to human diseases. This review summarizes findings of omics studies conducted on blood and tissue samples of people with acute Lyme disease and its postinfectious outcomes.<\/jats:p>","DOI":"10.1093\/infdis\/jiae250","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:46:44Z","timestamp":1723636004000},"page":"S18-S26","source":"Crossref","is-referenced-by-count":12,"title":["Insights From Omics in Lyme Disease"],"prefix":"10.1093","volume":"230","author":[{"given":"Linda K","family":"Bockenstedt","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale School of Medicine , New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia A","family":"Belperron","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale School of Medicine , New Haven, 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