{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:29Z","timestamp":1792839749451,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health and Care"},{"name":"Research"},{"DOI":"10.13039\/100018336","name":"Health Protection Research Unit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI087520"],"award-info":[{"award-number":["R01AI087520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008902","name":"Los Alamos National Laboratory","doi-asserted-by":"publisher","award":["20230873PRD4"],"award-info":[{"award-number":["20230873PRD4"]}],"id":[{"id":"10.13039\/100008902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis C virus (HCV) has high genetic diversity and is classified into 8 genotypes and &amp;gt;90 subtypes, with some endemic to specific world regions. This could compromise direct-acting antiviral efficacy and global HCV elimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We characterized HCV subtypes \u201crare\u201d in the United Kingdom (non-1a\/1b\/2b\/3a\/4d) by means of whole-genome sequencing via a national surveillance program. Genetic analyses to determine the genotype of samples with unresolved genotypes were undertaken by comparison with International Committee on Taxonomy of Viruses HCV reference sequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two HCV variants were characterized as being closely related to the recently identified genotype (GT) 8, with &amp;gt;85% pairwise genetic distance similarity to GT8 sequences and within the typical intersubtype genetic distance range. The individuals infected by the variants were UK residents originally from Pakistan and India. In contrast, a third variant was only confidently identified to be more similar to GT6 compared with other genotypes across 6% of the genome and was isolated from a UK resident originally from Guyana. All 3 were cured with pangenotypic direct-acting antivirals (sofosbuvir-velpatasvir or glecaprevir-pibrentasvir) despite the presence of resistance polymorphisms in NS3 (80K\/168E), NS5A (28V\/30S\/62L\/92S\/93S) and NS5B (159F).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study expands our knowledge of HCV diversity by identifying 2 new GT8 subtypes and potentially a new genotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiae253","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:54:31Z","timestamp":1715172871000},"page":"e1254-e1262","source":"Crossref","is-referenced-by-count":26,"title":["Identification of 2 Novel Subtypes of Hepatitis C Virus Genotype 8 and a Potential New Genotype Successfully Treated With Direct Acting Antivirals"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-9679","authenticated-orcid":false,"given":"Jean L","family":"Mbisa","sequence":"first","affiliation":[{"name":"Virus Reference Department, UK Health Security Agency , London ,","place":["United Kingdom"]},{"name":"National Institute for Health and Care Research Health Protection Research Unit (NIHR HPRU) in Bloodborne and Sexually Transmitted Infections , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Lapp","sequence":"additional","affiliation":[{"name":"Theoretical Biology and Biophysics Group, Los Alamos National Laboratory , Los Alamos, New Mexico ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Bibby","sequence":"additional","affiliation":[{"name":"Virus Reference Department, UK Health Security Agency , London ,","place":["United 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