{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:46:39Z","timestamp":1793148399055,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["CO-2016 02364534"],"award-info":[{"award-number":["CO-2016 02364534"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Latent tuberculosis infection is an asymptomatic infection caused by Mycobacterium tuberculosis. Previous studies have shown a host-protective role for heme oxygenase-1 (HO-1) during M. tuberculosis infection and an important involvement of glutathione peroxidase-4 (Gpx4) in the necrotic pathology of the disease. Furthermore, increasing evidence suggesting a crucial role for glutathione (GSH) in the granulomatous response to M. tuberculosis infection, with altered GSH levels associated with decreased host resistance. The aim of this study was to provide additional tools for discriminating between the pathologic tuberculosis state and asymptomatic infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed the expression of genes coding for HO-1 and GPX4 enzymes in blood of subjects with latent tuberculosis infection, active tuberculosis, and healthy controls, and we also measured blood levels of the reduced (GSH) and oxidized (GSSG) forms of glutathione, together with evaluation of GCL coding gene expression, responsible for GSH de novo synthesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our findings highlight a shift in glutathione homeostasis towards a more reducing conditions in latent tuberculosis infection, and a different modulation of GSH-dependent genes and HO-1 expression compared to active tuberculosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides useful tools to understand the redox background that directs the infection toward the asymptomatic or active disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae254","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T12:32:38Z","timestamp":1715257958000},"page":"e1162-e1170","source":"Crossref","is-referenced-by-count":3,"title":["Redox Biomarkers in Asymptomatic Latent Human Tuberculosis: A Comparison With Active Disease"],"prefix":"10.1093","volume":"230","author":[{"given":"Sara","family":"Petrillo","sequence":"first","affiliation":[{"name":"Unit of Muscular and Neurodegenerative Diseases, Children's Hospital Bambino Ges\u00f9, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reparata Rosa","family":"Di Prinzio","sequence":"additional","affiliation":[{"name":"Occupational Medicine Unit, Bambino Ges\u00f9 Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Quatrana","sequence":"additional","affiliation":[{"name":"Unit of Muscular and Neurodegenerative Diseases, Children's Hospital Bambino Ges\u00f9, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapaola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Occupational Medicine Unit, Bambino Ges\u00f9 Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Torda","sequence":"additional","affiliation":[{"name":"Unit of Muscular and Neurodegenerative Diseases, Children's Hospital Bambino Ges\u00f9, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Maria","family":"Mastroianni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Raponi","sequence":"additional","affiliation":[{"name":"Health Directorate, Bambino Ges\u00f9 Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) , Rome 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