{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:34:06Z","timestamp":1773477246869,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020955","name":"GlaxoSmithKline Biologicals SA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Determinants of maternal-fetal cytomegalovirus (CMV) transmission and factors influencing the severity of congenital CMV (cCMV) infection are not well understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a descriptive, multicenter study in pregnant women \u226518 years old with primary CMV infection and their newborns to explore maternal immune responses to CMV and determine potential immunologic\/virologic correlates of cCMV following primary infection during pregnancy. We developed alternative approaches looking into univariate\/multivariate factors associated with cCMV, including a participant clustering\/stratification approach and an interpretable predictive model\u2013based approach using trained decision trees for risk prediction (post hoc analyses).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Pregnant women were grouped in 3 distinct clusters with similar baseline characteristics, particularly gestational age at diagnosis. We observed a trend for higher viral loads in urine and saliva samples from mothers of infants with cCMV versus without cCMV. When using a trained predictive-model approach that accounts for interaction effects between variables, anti-pentamer immunoglobulin G antibody concentration and viral load in saliva were identified as biomarkers jointly associated with the risk of maternal-fetal CMV transmission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We identified biomarkers of CMV maternal-fetal transmission. After validation in larger studies, our findings will guide the management of primary infection during pregnancy and the development of vaccines against cCMV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT01251744.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae281","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:50:14Z","timestamp":1718142614000},"page":"e1274-e1286","source":"Crossref","is-referenced-by-count":2,"title":["Establishing Correlates of Maternal-Fetal Cytomegalovirus Transmission\u2014One Step Closer Through Predictive Modeling"],"prefix":"10.1093","volume":"230","author":[{"given":"Arnaud","family":"Marchant","sequence":"first","affiliation":[{"name":"European Plotkin Institute for Vaccinology, Universit\u00e9 libre de Bruxelles , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-9974","authenticated-orcid":false,"given":"Sancar","family":"Adali","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Alsdurf","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Bol","sequence":"additional","affiliation":[{"name":"GSK , Rixensart, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Capelle","sequence":"additional","affiliation":[{"name":"Domaine Universitaire du Sart-Tilman, Service de Gyn\u00e9cologie-Obst\u00e9trique, Centre Hospitalier Universitaire de Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"De Schrevel","sequence":"additional","affiliation":[{"name":"GSK , Rixensart, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Delroisse","sequence":"additional","affiliation":[{"name":"GSK , Wavre, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Devlieger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Belgium"},{"name":"Department of Obstetrics and Gynecology, GZA Ziekenhuizen\u2013Campus Sint-Augustinus , Wilrijk, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Dieussaert","sequence":"additional","affiliation":[{"name":"GSK , Rixensart, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Donner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Erasme , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Janssens","sequence":"additional","affiliation":[{"name":"GSK , Rixensart, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Loquet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, GZA Ziekenhuizen\u2013Campus Sint-Augustinus , Wilrijk, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil A","family":"Panackal","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Seidl","sequence":"additional","affiliation":[{"name":"GSK , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"van den Berg","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland, 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