{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:54:42Z","timestamp":1791258882092,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI075045"],"award-info":[{"award-number":["R01AI075045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI089674"],"award-info":[{"award-number":["U19AI089674"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI139520"],"award-info":[{"award-number":["R01AI139520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI173557"],"award-info":[{"award-number":["R01AI173557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","award":["01407"],"award-info":[{"award-number":["01407"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Newly arrived refugees offer insights into malaria epidemiology in their countries of origin. We evaluated asymptomatic refugee children within 7 days of arrival in Uganda from South Sudan and the Democratic Republic of Congo (DRC) in 2022 for parasitemia, parasite species, and Plasmodium falciparum drug resistance markers. Asymptomatic P. falciparum infections were common in both populations. Coinfection with P. malariae was more common in DRC refugees. Prevalences of markers of aminoquinoline resistance (PfCRT K76T, PfMDR1 N86Y) were much higher in South Sudan refugees, of antifolate resistance (PfDHFR C59R and I164L, PfDHPS A437G, K540E, and A581G) much higher in DRC refugees, and of artemisinin partial resistance (ART-R; PfK13 C469Y and A675V) moderate in both populations. Prevalences of most mutations differed from those seen in Ugandans attending health centers near the refugee centers. Refugee evaluations yielded insights into varied malaria epidemiology and identified markers of ART-R in 2 previously little-studied countries.<\/jats:p>","DOI":"10.1093\/infdis\/jiae288","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T21:26:39Z","timestamp":1718227599000},"page":"497-504","source":"Crossref","is-referenced-by-count":15,"title":["Varied Prevalence of Antimalarial Drug Resistance Markers in Different Populations of Newly Arrived Refugees in Uganda"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-6516","authenticated-orcid":false,"given":"Stephen","family":"Tukwasibwe","sequence":"first","affiliation":[{"name":"Makerere University , Kampala , Uganda"},{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"},{"name":"Uganda Christian University , Mukono , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreeya","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Katairo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-4692","authenticated-orcid":false,"given":"Victor","family":"Asua","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A","family":"Kagurusi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-9414","authenticated-orcid":false,"given":"Gerald","family":"Mboowa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute , Kampala , Uganda"},{"name":"Africa Centers for Disease Control and Prevention , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Crudale","sequence":"additional","affiliation":[{"name":"Brown University , Providence, Rhode Island , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Tumusiime","sequence":"additional","affiliation":[{"name":"Uganda Christian University , Mukono , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Businge","sequence":"additional","affiliation":[{"name":"Medical Teams International , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alula","sequence":"additional","affiliation":[{"name":"Medical Teams International , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Kasozi","sequence":"additional","affiliation":[{"name":"United Nations High Commissioner for Refugees , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Wadembere","sequence":"additional","affiliation":[{"name":"United Nations High Commissioner for Refugees , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Ssewanyana","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaniter I","family":"Nankabirwa","sequence":"additional","affiliation":[{"name":"Makerere University , Kampala , Uganda"},{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L","family":"Nsobya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R","family":"Kamya","sequence":"additional","affiliation":[{"name":"Makerere University , Kampala , Uganda"},{"name":"Infectious Diseases Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Greenhouse","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-8204","authenticated-orcid":false,"given":"Jeffrey A","family":"Bailey","sequence":"additional","affiliation":[{"name":"Brown University , Providence, Rhode Island , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8078-3898","authenticated-orcid":false,"given":"Jessica","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"2024081523524024200_jiae288-B1","volume-title":"World malaria report","author":"World Health Organization","year":"2023"},{"key":"2024081523524024200_jiae288-B2","volume-title":"WHO guidelines for malaria","author":"World Health Organization","year":"2023"},{"key":"2024081523524024200_jiae288-B3","doi-asserted-by":"crossref","first-page":"102193","DOI":"10.1016\/j.mib.2022.102193","article-title":"Plasmodium falciparum resistance to artemisinin-based combination therapies","volume":"69","author":"Ward","year":"2022","journal-title":"Curr Opin Microbiol"},{"key":"2024081523524024200_jiae288-B4","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1016\/S1473-3099(19)30261-0","article-title":"Antimalarial drug resistance in Africa: the calm before the storm?","volume":"19","author":"Conrad","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2024081523524024200_jiae288-B5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/infdis\/jiaa687","article-title":"Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda","volume":"223","author":"Asua","year":"2021","journal-title":"J Infect Dis"},{"key":"2024081523524024200_jiae288-B6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/QCO.0000000000000766","article-title":"Artemisinin and multidrug-resistant Plasmodium falciparum\u2014a threat for malaria control and elimination","volume":"34","author":"Dhorda","year":"2021","journal-title":"Curr Opin Infect Dis"},{"key":"2024081523524024200_jiae288-B7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41579-024-01008-2","article-title":"Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa","volume":"22","author":"Rosenthal","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"2024081523524024200_jiae288-B8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1056\/NEJMoa2211803","article-title":"Evolution of partial resistance to artemisinins in malaria parasites in Uganda","volume":"389","author":"Conrad","year":"2023","journal-title":"N Engl J Med"},{"key":"2024081523524024200_jiae288-B9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pedn.2021.06.001","article-title":"Health of African refugee children outside Africa: a scoping review","volume":"61","author":"Salami","year":"2021","journal-title":"J Pediatr Nurs"},{"key":"2024081523524024200_jiae288-B10","doi-asserted-by":"crossref","first-page":"e107693","DOI":"10.1371\/journal.pone.0107693","article-title":"Asymptomatic malaria in refugees living in a non-endemic South African city","volume":"9","author":"Tsoka-Gwegweni","year":"2014","journal-title":"PLoS One"},{"key":"2024081523524024200_jiae288-B11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12913-018-3366-5","article-title":"Quality of care for children with acute malnutrition at health center level in Uganda: a cross sectional study in west Nile region during the refugee crisis","volume":"18","author":"Wanzira","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"2024081523524024200_jiae288-B12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40249-023-01090-3","article-title":"Determinants of malaria infections among children in refugee settlements in Uganda during 2018\u20132019","volume":"12","author":"Semakula","year":"2023","journal-title":"Infect Dis Poverty"},{"key":"2024081523524024200_jiae288-B13","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/s41467-021-22896-5","article-title":"The impact of stopping and starting indoor residual spraying on malaria burden in Uganda","volume":"12","author":"Namuganga","year":"2021","journal-title":"Nat Commun"},{"key":"2024081523524024200_jiae288-B14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4269\/ajtmh.1995.52.565","article-title":"Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa","volume":"52","author":"Plowe","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"2024081523524024200_jiae288-B15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0166-6851(93)90050-8","article-title":"Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections","volume":"58","author":"Snounou","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"2024081523524024200_jiae288-B16","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/infdis\/jiy223","article-title":"Drug resistance and population structure of Plasmodium falciparum across the democratic Republic of Congo using high-throughput molecular inversion probes","volume":"218","author":"Aydemir","year":"2018","journal-title":"J Infect Dis"},{"key":"2024081523524024200_jiae288-B17","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1128\/JCM.00904-13","article-title":"Optimization of a ligase detection reaction fluorescent microsphere assay for the characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum","volume":"51","author":"Leclair","year":"2013","journal-title":"J Clin Microbiol"},{"key":"2024081523524024200_jiae288-B18","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/1755-0998.12639","article-title":"Resolving microsatellite genotype ambiguity in populations of allopolyploid and diploidized autopolyploid organisms using negative correlations between allelic variables","volume":"17","author":"Clark","year":"2017","journal-title":"Mol Ecol Resour"},{"key":"2024081523524024200_jiae288-B19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijid.2023.11.026","article-title":"Identification of the PfK13 mutations R561H and P441L in the democratic Republic of Congo","volume":"139","author":"Mesia Kahunu","year":"2024","journal-title":"Int J Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae288\/58375745\/jiae288.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/2\/497\/58809183\/jiae288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/2\/497\/58809183\/jiae288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T23:54:21Z","timestamp":1723766061000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/230\/2\/497\/7693370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,14]]},"published-print":{"date-parts":[[2024,8,16]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae288","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8,15]]},"published":{"date-parts":[[2024,6,14]]}}}