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Evidence of TDR was defined by the World Health Organization list for surveillance of drug resistance mutations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 22 124 PWH with protease and reverse transcriptase sequences, 965 (4.36%; 95% CI, 4.1\u20134.63) had at least 1 TDR mutation. The most frequent TDR mutations were nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.39%; 95% CI, 2.19%\u20132.59%), followed by nucleoside reverse transcriptase inhibitor mutations(1.35%; 95% CI, 1.2%\u20131.5%) and protease inhibitor mutations (1.12%; 95% CI, .98%\u20131.26%). The overall protease and reverse transcriptase TDR increased significantly from 4.05% (95% CI, 3.61%\u20134.52%) in 2018 to 5.39% (95% CI, 4.33%\u20136.57%) in 2023. A low level of integrase strand transfer inhibitor TDR was detected in 9 (0.21%; 95% CI, .1%\u2013.38%) of 4205 PWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Presently, the continued use of NNRTI-based first-line antiretroviral therapy regimen for HIV treatment has been justified.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae303","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T13:21:42Z","timestamp":1724764902000},"page":"1410-1421","source":"Crossref","is-referenced-by-count":12,"title":["Trends and Patterns of HIV Transmitted Drug Resistance in China From 2018 to 2023"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-7148","authenticated-orcid":false,"given":"Jingrong","family":"Ye","sequence":"first","affiliation":[{"name":"Institute for HIV\/AIDS and STD Prevention and 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Preventive Medicine, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of AIDS\/STD Control and Prevention, Jiangsu CDC , Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-5638","authenticated-orcid":false,"given":"Jinjin","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Affiliated Infectious Diseases Hospital of Zhengzhou University (Henan Infectious Diseases Hospital, The Sixth People's Hospital of Zhengzhou), Zhengzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for AIDS\/STD Control and Prevention, Sichuan CDC , 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