{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:10:37Z","timestamp":1770743437919,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010127","name":"J\u00fcrgen Manchot Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cluster of Excellence ImmunoSensation2","award":["390873048"],"award-info":[{"award-number":["390873048"]}]},{"name":"IRTG 2168","award":["272482170"],"award-info":[{"award-number":["272482170"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>By acting as an environmental sensor, the ligand-induced transcription factor aryl hydrocarbon receptor (AhR) regulates acute innate and adaptive immune responses against pathogens. Here, we analyzed the function of AhR in a model for chronic systemic infection with attenuated Salmonella Typhimurium (STM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Wild type and AhR-deficient mice were infected with the attenuated STM strain TAS2010 and analyzed for bacterial burden, host defense functions, and inflammatory stress erythropoiesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AhR-deficient mice were highly susceptible to TAS2010 infection when compared with wild type mice, as demonstrated by reduced bacterial clearance and increased mortality. STM infection resulted in macrocytic anemia and enhanced splenomegaly with destruction of the splenic architecture in AhR-deficient mice. In addition, AhR-deficient mice displayed a major expansion of splenic immature red blood cells, indicative of infection-induced stress erythropoiesis. Elevated serum levels of erythropoietin and interleukin 6 upon infection, as well as increased numbers of splenic stress erythroid progenitors already in steady state, probably drive this effect and might cause the alterations in splenic immune cell compartments, thereby preventing an effective host defense against STM in AhR-deficient mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AhR-deficient mice fail to clear chronic TAS2010 infection due to enhanced stress erythropoiesis in the spleen and accompanying destruction of the splenic architecture.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae304","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T11:47:27Z","timestamp":1717674447000},"page":"318-328","source":"Crossref","is-referenced-by-count":2,"title":["Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to <i>Salmonella<\/i> Typhimurium Infection in Aryl Hydrocarbon Receptor\u2013Deficient Mice"],"prefix":"10.1093","volume":"231","author":[{"given":"Michelle","family":"Mayer","sequence":"first","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi C","family":"Cengiz-Dartenne","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"},{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf, Heinrich-Heine-University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manja","family":"Thiem","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"},{"name":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Hatzfeld","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Semeniuk","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"},{"name":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Strugnell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-5890","authenticated-orcid":false,"given":"Heike","family":"Weighardt","sequence":"additional","affiliation":[{"name":"Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Germany"},{"name":"Innate Immunity and Extrinsic Skin 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