{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:27Z","timestamp":1782902067521,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eunice Kennedy Shriver"},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UM1AI068632-15"],"award-info":[{"award-number":["UM1AI068632-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UM1AI068616-15"],"award-info":[{"award-number":["UM1AI068616-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UM1AI106716-15"],"award-info":[{"award-number":["UM1AI106716-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN275201800001I"],"award-info":[{"award-number":["HHSN275201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K24 AI131928"],"award-info":[{"award-number":["K24 AI131928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2010\/VESTED study, pregnant women were randomized to initiate dolutegravir (DTG) + emtricitabine (FTC)\/tenofovir alafenamide (TAF), DTG + FTC\/tenofovir disoproxil fumarate (TDF), or efavirenz (EFV)\/FTC\/TDF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed red blood cell (RBC) folate concentrations at maternal study entry and delivery, and infant birth. RBC folate outcomes were (1) maternal change entry to delivery (trajectory), (2) infant, and (3) ratio of infant-to-maternal delivery. Generalized estimating equation models for each log(folate) outcome were fit to estimate adjusted geometric mean ratio (Adj-GMR)\/GMR trajectories (Adj-GMRTs) of each arm comparison in 340 mothers and 310 infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 90% of mothers received folic acid supplements and 78% lived in Africa. At entry, median maternal age was 25 years, gestational age was 22 weeks, CD4 count was 482 cells\/\u03bcL, and log10 HIV RNA was 3 copies\/mL. Entry RBC folate was similar across arms. Adj-GMRT of maternal folate was 3% higher in the DTG + FTC\/TAF versus EFV\/FTC\/TDF arm (1.03 [95% confidence interval {CI}, 1.00\u20131.06]). The DTG + FTC\/TAF arm had an 8% lower infant-maternal folate ratio (0.92 [95% CI, .78\u20131.09]) versus EFV\/FTC\/TDF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results are consistent, with no clinically meaningful differences between arms for all RBC folate outcomes, and they suggest that cellular uptake of folate and folate transport to the infant do not differ in pregnant women starting DTG- versus EFV-based antiretroviral therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT03048422.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae308","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:33:34Z","timestamp":1718260414000},"page":"1224-1234","source":"Crossref","is-referenced-by-count":2,"title":["Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-7148","authenticated-orcid":false,"given":"Denise L","family":"Jacobson","sequence":"first","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista S","family":"Crider","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"DeMarrais","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Brummel","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A","family":"Moore","sequence":"additional","affiliation":[{"name":"Goldbelt Professional Services, LLC , Chesapeake, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"McCarthy","sequence":"additional","affiliation":[{"name":"FHI 360 , Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Johnston","sequence":"additional","affiliation":[{"name":"Frontier Science Foundation , Amherst, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tichaona","family":"Vhembo","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre , Harare, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enid","family":"Kabugho","sequence":"additional","affiliation":[{"name":"Makarere University-Johns Hopkins University Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald Agaba","family":"Muzorah","sequence":"additional","affiliation":[{"name":"Clinical Research site, Baylor-Uganda , Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseena","family":"Cassim","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersand, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Wits RHI, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S","family":"Ngocho","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical University College , Moshi ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. 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Chan School of Public Health , Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Serghides","sequence":"additional","affiliation":[{"name":"University Health Network and Department of Immunology and Institute of Medical Sciences, University of Toronto , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahida","family":"Chakhtoura","sequence":"additional","affiliation":[{"name":"Pregnancy and Perinatal Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lameck","family":"Chinula","sequence":"additional","affiliation":[{"name":"University of North Carolina Project\u2013Malawi , Lilongwe, Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Lockman","sequence":"additional","affiliation":[{"name":"Botswana Harvard Health Partnership, Brigham and Women's Hospital"},{"name":"Harvard T. 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pathways","volume":"47","author":"Zamek-Gliszczynski","year":"2019","journal-title":"Drug Metab Dispo"},{"key":"2024111514542934800_jiae308-B14","doi-asserted-by":"crossref","first-page":"e26174","DOI":"10.1002\/jia2.26174","article-title":"Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trial","volume":"26","author":"Barlow-Mosha","year":"2023","journal-title":"J Int AIDS Soc"},{"key":"2024111514542934800_jiae308-B15","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(21)00314-7","article-title":"Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010\/VESTED): a multicentre, open-label, randomised, controlled, phase 3 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