{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:54:18Z","timestamp":1788357258639,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illness (ARI) in older adults. Optimizing diagnosis could improve understanding of RSV burden.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled adults \u226550 years of age hospitalized with ARI and adults of any age hospitalized with congestive heart failure or chronic obstructive pulmonary disease exacerbations at 2 hospitals during 2 respiratory seasons (2018\u20132020). We collected nasopharyngeal (NP) and oropharyngeal (OP) swabs (n = 1558), acute and convalescent sera (n = 568), and expectorated sputum (n = 153) from participants, and recorded standard-of-care (SOC) NP results (n = 805). We measured RSV antibodies by 2 immunoassays and performed BioFire testing on respiratory specimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1558 eligible participants, 92 (5.9%) tested positive for RSV by any diagnostic method. Combined NP\/OP polymerase chain reaction (PCR) testing yielded 58 positives, while separate NP and OP testing identified 11 additional positives (18.9% increase). Compared to study NP\/OP PCR alone, the addition of paired serology increased RSV detection by 42.9% (28 vs 40) among those with both specimen types, while the addition of SOC swab PCR increased RSV detection by 25.9% (47 vs 59).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The addition of paired serology testing, SOC swab results, and separate testing of NP and OP swabs improved RSV diagnostic yield in hospitalized adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae346","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T13:58:57Z","timestamp":1720792737000},"page":"1342-1351","source":"Crossref","is-referenced-by-count":13,"title":["Relative Contribution of Diagnostic Testing to the Diagnosis of Respiratory Syncytial Virus in Hospitalized Adults in the United States"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-4420","authenticated-orcid":false,"given":"Evan J","family":"Anderson","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Tippett","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-5416","authenticated-orcid":false,"given":"Elizabeth","family":"Begier","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theda","family":"Gibson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabby","family":"Ess","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikash","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Reese","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Salazar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samadhan","family":"Jadhao","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mien","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadwal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Stephens","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Keane","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ciric","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieffer","family":"Hellmeister","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zayna","family":"Al-Husein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Bristow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Hubler","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford D","family":"Gessner","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1246-530X","authenticated-orcid":false,"given":"Luis","family":"Jodar","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Kalina","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Uppal","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc , Collegeville, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-0700","authenticated-orcid":false,"given":"Satoshi","family":"Kamidani","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-7919","authenticated-orcid":false,"given":"Nadine","family":"Rouphael","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-0592","authenticated-orcid":false,"given":"Christina A","family":"Rostad","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]},{"name":"Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"2024121523530157000_jiae346-B1","doi-asserted-by":"crossref","first-page":"ofac300","DOI":"10.1093\/ofid\/ofac300","article-title":"Rates of medically attended RSV among US adults: a systematic review and meta-analysis","volume":"9","author":"McLaughlin","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2024121523530157000_jiae346-B2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.15585\/mmwr.mm7224a3","article-title":"Interim recommendations for use of bivalent mRNA COVID-19 vaccines for persons aged \u22656 months\u2014United States, April 2023","volume":"72","author":"Moulia","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024121523530157000_jiae346-B3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/17476348.2019.1555040","article-title":"Epidemiology of lower respiratory tract infections in adults","volume":"13","author":"Feldman","year":"2019","journal-title":"Expert Rev Respir Med"},{"key":"2024121523530157000_jiae346-B4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1500245","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. adults","volume":"373","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"2024121523530157000_jiae346-B5","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"352","author":"Falsey","year":"2005","journal-title":"N Engl J Med"},{"key":"2024121523530157000_jiae346-B6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/187152612800100116","article-title":"Respiratory syncytial virus infection in adult populations","volume":"12","author":"Walsh","year":"2012","journal-title":"Infect Disord Drug Targets"},{"key":"2024121523530157000_jiae346-B7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/s-0031-1283282","article-title":"Respiratory syncytial virus infection in adults","volume":"32","author":"Walsh","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"2024121523530157000_jiae346-B8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1164\/rccm.200510-1681OC","article-title":"Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease","volume":"173","author":"Falsey","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2024121523530157000_jiae346-B9","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/infdis\/jit832","article-title":"Respiratory syncytial virus in hematopoietic cell transplant recipients: factors determining progression to lower respiratory tract disease","volume":"209","author":"Kim","year":"2014","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B10","doi-asserted-by":"crossref","first-page":"e0264890","DOI":"10.1371\/journal.pone.0264890","article-title":"Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure-United States, 2015\u20132017","volume":"17","author":"Kujawski","year":"2022","journal-title":"PLoS One"},{"key":"2024121523530157000_jiae346-B11","doi-asserted-by":"crossref","first-page":"ofad513","DOI":"10.1093\/ofid\/ofad513","article-title":"Systematic literature review of risk factors for poor outcomes among adults with respiratory syncytial virus infection in high-income countries","volume":"10","author":"Njue","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"2024121523530157000_jiae346-B12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States","volume":"289","author":"Thompson","year":"2003","journal-title":"JAMA"},{"key":"2024121523530157000_jiae346-B13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/infdis\/174.3.456","article-title":"Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults","volume":"174","author":"Dowell","year":"1996","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s40121-023-00758-5","article-title":"Low levels of RSV testing among adults hospitalized for lower respiratory tract infection in the United States","volume":"12","author":"Rozenbaum","year":"2023","journal-title":"Infect Dis Ther"},{"key":"2024121523530157000_jiae346-B15","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s40121-023-00802-4","article-title":"Incidence of respiratory syncytial virus infection in older adults: limitations of current data","volume":"12","author":"Rozenbaum","year":"2023","journal-title":"Infect Dis Ther"},{"key":"2024121523530157000_jiae346-B16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1386-6532(03)00002-7","article-title":"Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults","volume":"28","author":"Casiano-Col\u00f3n","year":"2003","journal-title":"J Clin Virol"},{"key":"2024121523530157000_jiae346-B17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/ijerph17020564","article-title":"Increased detection of viruses in children with respiratory tract infection using PCR","volume":"17","author":"Lin","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"2024121523530157000_jiae346-B18","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/jmv.26369","article-title":"Evaluation of immuview RSV antigen test (SSI Siagnostica) and BinaxNOW RSV card (Alere) for rapid detection of respiratory syncytial virus in retrospectively and prospectively collected respiratory samples","volume":"92","author":"Franck","year":"2020","journal-title":"J Med Virol"},{"key":"2024121523530157000_jiae346-B19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1086\/338238","article-title":"Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia","volume":"34","author":"van Elden","year":"2002","journal-title":"Clin Infect Dis"},{"key":"2024121523530157000_jiae346-B20","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1128\/JCM.01816-15","article-title":"Diagnostic accuracy of rapid antigen detection tests for respiratory syncytial virus infection: systematic review and meta-analysis","volume":"53","author":"Chartrand","year":"2015","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B21","doi-asserted-by":"crossref","first-page":"636","DOI":"10.5858\/arpa.2014-0257-OA","article-title":"Impact of a rapid respiratory panel test on patient outcomes","volume":"139","author":"Rogers","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"2024121523530157000_jiae346-B22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/infdis\/jiad012","article-title":"Underascertainment of respiratory syncytial virus infection in adults due to diagnostic testing limitations: a systematic literature review and meta-analysis","volume":"228","author":"Onwuchekwa","year":"2023","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B23","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/infdis\/jit038","article-title":"Viral shedding and immune responses to respiratory syncytial virus infection in older adults","volume":"207","author":"Walsh","year":"2013","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s40121-023-00805-1","article-title":"Diagnosis of respiratory syncytial virus in adults substantially increases when adding sputum, saliva, and serology testing to nasopharyngeal swab RT-PCR","volume":"12","author":"Ramirez","year":"2023","journal-title":"Infect Dis Ther"},{"key":"2024121523530157000_jiae346-B25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJMc2016359","article-title":"Saliva or nasopharyngeal swab specimens for detection of SARS-CoV-2","volume":"383","author":"Wyllie","year":"2020","journal-title":"N Engl J Med"},{"key":"2024121523530157000_jiae346-B26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/infdis\/jiy106","article-title":"Virus-specific antibody, viral load, and disease severity in respiratory syncytial virus infection","volume":"218","author":"Walsh","year":"2018","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/14737159.2018.1487293","article-title":"Rapid and simple molecular tests for the detection of respiratory syncytial virus: a review","volume":"18","author":"Hogan","year":"2018","journal-title":"Expert Rev Mol Diagn"},{"key":"2024121523530157000_jiae346-B28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/JCM.01701-16","article-title":"Serology enhances molecular diagnosis of respiratory virus infections other than influenza in children and adults hospitalized with community-acquired pneumonia","volume":"55","author":"Zhang","year":"2017","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/JCM.05841-11","article-title":"Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness","volume":"50","author":"Falsey","year":"2012","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B30","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1128\/JCM.01523-14","article-title":"Detection of respiratory viruses in sputum from adults by use of automated multiplex PCR","volume":"52","author":"Branche","year":"2014","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B31","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/infdis\/jiad185","article-title":"Pediatric respiratory syncytial virus diagnostic testing performance: a systematic review and meta-analysis","volume":"228","author":"Onwuchekwa","year":"2023","journal-title":"J Infect Dis"},{"key":"2024121523530157000_jiae346-B32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1056\/NEJMoa2209604","article-title":"Respiratory syncytial virus prefusion F protein vaccine in older adults","volume":"388","author":"Papi","year":"2023","journal-title":"N Engl J Med"},{"key":"2024121523530157000_jiae346-B33","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1056\/NEJMoa2213836","article-title":"Efficacy and safety of a bivalent RSV prefusion f vaccine in older adults","volume":"388","author":"Walsh","year":"2023","journal-title":"N Engl J Med"},{"key":"2024121523530157000_jiae346-B34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.15585\/mmwr.mm7229a4","article-title":"Use of respiratory syncytial virus vaccines in older adults: recommendations of the advisory committee on immunization practices\u2014United States, 2023","volume":"72","author":"Melgar","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024121523530157000_jiae346-B35","author":"CDC"},{"key":"2024121523530157000_jiae346-B36","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/cid\/ciab595","article-title":"Incidence of respiratory syncytial virus infection among hospitalized adults, 2017\u20132020","volume":"74","author":"Branche","year":"2022","journal-title":"Clin Infect Dis"},{"key":"2024121523530157000_jiae346-B37","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.ajt.2023.10.010","article-title":"Characteristics and outcomes among adults aged \u226560 years hospitalized with laboratory-confirmed respiratory syncytial virus\u2014RSV-NET, 12 states, July 2022-June 2023","volume":"23","author":"Havers","year":"2023","journal-title":"Am J Transplant"},{"key":"2024121523530157000_jiae346-B38","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/JCM.01473-12","article-title":"Simple method for combining sputum and nasal samples for virus detection by reverse transcriptase PCR","volume":"50","author":"Falsey","year":"2012","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B39","doi-asserted-by":"crossref","first-page":"e26047","DOI":"10.1371\/journal.pone.0026047","article-title":"FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection","volume":"6","author":"Poritz","year":"2011","journal-title":"PLoS One"},{"key":"2024121523530157000_jiae346-B40","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/JCM.05996-11","article-title":"Comparison of the Idaho technology FilmArray system to real-time PCR for detection of respiratory pathogens in children","volume":"50","author":"Pierce","year":"2012","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1586\/14737159.2013.848794","article-title":"The FilmArray\u00ae respiratory panel: an automated, broadly multiplexed molecular test for the rapid and accurate detection of respiratory pathogens","volume":"13","author":"Babady","year":"2013","journal-title":"Expert Rev Mol Diagn"},{"key":"2024121523530157000_jiae346-B42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4939-3687-8_4","article-title":"Detection of RSV antibodies in human plasma by enzyme immunoassays","volume":"1442","author":"Jadhao","year":"2016","journal-title":"Methods Mol Biol"},{"key":"2024121523530157000_jiae346-B43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jgg.2021.07.007","article-title":"EVenn: easy to create repeatable and editable Venn diagrams and Venn networks online","volume":"48","author":"Chen","year":"2021","journal-title":"J Genet Genomics"},{"key":"2024121523530157000_jiae346-B44","first-page":"84","article-title":"A case study in fitting area-proportional Euler diagrams with ellipses using eulerr","author":"Larsson","year":"2018"},{"key":"2024121523530157000_jiae346-B45","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/aje\/kwab181","article-title":"Risk of transmission and viral shedding from the time of infection for respiratory syncytial virus in households","volume":"190","author":"Otomaru","year":"2021","journal-title":"Am J Epidemiol"},{"key":"2024121523530157000_jiae346-B46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/d41573-023-00085-x","article-title":"RSV vaccines score landmark FDA approvals","volume":"190","author":"Kingwell","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"2024121523530157000_jiae346-B47","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1128\/JCM.40.3.817-820.2002","article-title":"Diagnosis of respiratory syncytial virus infection: comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness","volume":"40","author":"Falsey","year":"2002","journal-title":"J Clin Microbiol"},{"key":"2024121523530157000_jiae346-B48","doi-asserted-by":"crossref","first-page":"2002688","DOI":"10.1183\/13993003.02688-2020","article-title":"Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study","volume":"57","author":"Korsten","year":"2021","journal-title":"Eur Respir J"},{"key":"2024121523530157000_jiae346-B49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jmv.25285","article-title":"Respiratory syncytial virus-associated illness in adults with advanced chronic obstructive pulmonary disease and\/or congestive heart failure","volume":"91","author":"Falsey","year":"2019","journal-title":"J Med Virol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae346\/58624323\/jiae346.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/6\/1342\/61141790\/jiae346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/230\/6\/1342\/61141790\/jiae346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T23:53:22Z","timestamp":1734306802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/230\/6\/1342\/7712684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,7,12]]},"published-print":{"date-parts":[[2024,12,16]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae346","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12,15]]},"published":{"date-parts":[[2024,7,12]]}}}