{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:51:22Z","timestamp":1774687882618,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"FluGen, Inc"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:p>Intranasal H3N2 M2SR vaccine induced cross-reactive mucosal IgA antibodies against a panel of H3N2 hemagglutinins, ranging from 1968 to 2014, in adults independent of baseline immune status. The breadth extended to potential pandemic strain H7N9, presumably through the hemagglutinin stem.<\/jats:p>\n                  <jats:p>Intranasal M2SR (M2-deficient single replication) influenza virus vaccine induces robust immune responses in animal models and humans. A high-throughput multiplexed platform was used to analyze hemagglutinin-specific mucosal antibody responses in adults after a single dose of H3N2 M2SR. Nasal swab specimens were analyzed for total and hemagglutinin-specific IgA. Significant dose-dependent increases in mucosal antibody responses to vaccine-matched and drifted H3N2 hemagglutinin were observed in persons vaccinated with M2SR regardless of baseline serum and mucosal immune status. These data suggest that M2SR induces broadly cross-reactive mucosal immune responses, which may provide better protection against drifted and newly emerging influenza strains.<\/jats:p>","DOI":"10.1093\/infdis\/jiae361","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T17:06:39Z","timestamp":1720803999000},"page":"214-218","source":"Crossref","is-referenced-by-count":1,"title":["Intranasal M2SR (M2-Deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults"],"prefix":"10.1093","volume":"231","author":[{"given":"Lindsay","family":"Hill-Batorski","sequence":"first","affiliation":[{"name":"FluGen, Inc , Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A","family":"Weiner","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College , Hanover, New 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