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People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.<\/jats:p>","DOI":"10.1093\/infdis\/jiae362","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T04:53:34Z","timestamp":1720846414000},"page":"912-918","source":"Crossref","is-referenced-by-count":0,"title":["Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV"],"prefix":"10.1093","volume":"230","author":[{"given":"Priyesh","family":"Agrawal","sequence":"first","affiliation":[{"name":"Adaptive Phage Therapeutics , Gaithersburg, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila B","family":"Giron","sequence":"additional","affiliation":[{"name":"The Wistar Institute , Philadelphia, Pennsylvania 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