{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:06:04Z","timestamp":1791313564110,"version":"4.3.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"name":"Government of India's"},{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"Office of AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"name":"(support to S. 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In this study, we aimed to determine plasma immune biomarker profiles in healthy household contacts of index patients with pulmonary tuberculosis, who either progressed to tuberculosis or remained as nonprogressors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of household contacts of adults with pulmonary tuberculosis was enrolled, consisting of 15 contacts who progressed to tuberculosis disease and 15 nonprogressors. Plasma samples were collected at baseline, 4 months, and 12 months to identify predictive tuberculosis progression markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our findings revealed that individuals in the progressor group exhibited significantly decreased levels of interferon (IFN) \u03b3, tumor necrosis factor \u03b1, interleukin 2, IL-1\u03b1, IL-1\u03b2, and 17A, and interleukin 1 receptor antagonist (IL-1Ra) at baseline, month 4, and month 12. In contrast, the progressor group displayed significantly elevated levels of IFN-\u03b1, IFN-\u03b2, interleukin 6 and 12, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 10 (IL-10) and 33 (IL-33), CCL2, CCL11, CXCL8, CXCL10, CX3CL1, vascular endothelial growth factor, granzyme B, and programmed death ligand -1 compared to the nonprogressor group at baseline, months 4 and 12. Receiver operating characteristic analysis (ROC) identified IFN-\u03b3, GM-CSF, IL-1Ra, CCL2, and CXCL10 as the most promising predictive markers, with an area under the receiver operating characteristic curve of \u226590. Furthermore, combinatorial analysis demonstrated that GM-CSF, CXCL10, and IL-1Ra, when used in combination, exhibited high accuracy in predicting progression to active tuberculosis disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study suggests that a specific set of plasma biomarkers, GM-CSF, CXCL10, and IL-1Ra, can effectively identify household contacts at significant risk of developing tuberculosis disease. These findings have important implications for early intervention and preventive strategies in tuberculosis-endemic regions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae365","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T10:13:00Z","timestamp":1721383980000},"page":"696-705","source":"Crossref","is-referenced-by-count":13,"title":["Plasma Immune Biomarkers Predictive of Progression to Active Tuberculosis in Household Contacts of Patients With Tuberculosis"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-5502","authenticated-orcid":false,"given":"Anuradha","family":"Rajamanickam","sequence":"first","affiliation":[{"name":"National Institute of Health-National Institute of Allergy and Infectious Diseases\u2013International Center for Excellence in Research , Chennai ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangeline","family":"Ann Daniel","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Indian Council of Medical Research , Chennai ,","place":["India"]},{"name":"University of Madras , Chennai ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Dasan","sequence":"additional","affiliation":[{"name":"National Institute of Health-National Institute of Allergy and Infectious Diseases\u2013International Center for Excellence in Research , Chennai ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Thiruvengadam","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Indian Council of Medical Research , Chennai ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmapriyadarsini","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research 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,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amsaveni","family":"Sivaprakasam","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Indian Council of Medical Research , Chennai ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2013Johns Hopkins Clinical Research Site , Pune ,","place":["India"]},{"name":"Johns Hopkins Center for Infectious Diseases in India , Pune ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Karyakarte","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals , Pune ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandar","family":"Paradkar","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2013Johns Hopkins Clinical Research Site , Pune ,","place":["India"]},{"name":"Johns Hopkins Center for Infectious Diseases in India , Pune ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shri Vijay Bala Yogendra","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Johns Hopkins Center for Infectious Diseases in India , Pune ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-4517","authenticated-orcid":false,"given":"Vidya","family":"Mave","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2013Johns Hopkins Clinical Research Site , Pune ,","place":["India"]},{"name":"Johns Hopkins Center for Infectious Diseases in 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