{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:49:42Z","timestamp":1791838182500,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CK14-140105PPHF18"],"award-info":[{"award-number":["CK14-140105PPHF18"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CK19-1904"],"award-info":[{"award-number":["CK19-1904"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We assessed human papillomavirus (HPV) vaccine effectiveness (VE) against anal HPV among men who have sex with men (MSM) in 2018\u20132023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Residual anal specimens from MSM without HIV aged 18\u201345 years were tested for HPV. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) for associations between vaccination (\u22651 dose) and quadrivalent vaccine (4vHPV)-type prevalence adjusting for city, race\/ethnicity, and nonvaccine-type HPV prevalence, stratified by age group (18\u201326, 27\u201345 years). VE was calculated as (1 \u2212 aPR) \u00d7 100.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 2802 persons aged 18\u201326, 4vHPV-type prevalence was lower in those vaccinated at age &amp;lt;18 (aPR = 0.13; 95% CI, .08\u2013.22; VE = 87%) and those vaccinated \u22652 years before specimen collection (aPR = 0.52; 95% CI, .42\u2013.64; VE = 48%) compared with unvaccinated persons. Among 3548 persons aged 27\u201345, 4vHPV-type prevalence was lower in those vaccinated at ages 18\u201326 (aPR = 0.68; 95% CI, .57\u2013.82; VE = 32%) and those vaccinated \u22652 years before specimen collection (aPR = 0.66; 95% CI, .57\u2013.77; VE = 33%) compared with unvaccinated persons. While we observed no VE in persons vaccinated at age &amp;gt;26 overall, 4vHPV-type prevalence was lower in the subgroup vaccinated \u22652 years before specimen collection (aPR = 0.71; 95% CI, .56\u2013.89; VE = 29%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found high VE against anal 4vHPV-type prevalence among MSM aged 18\u201326 who were vaccinated at age &amp;lt;18. Lower VE was observed among MSM aged 27\u201345 who were vaccinated at age 18\u201326 or \u22652 years before specimen collection. While ideally vaccination should be given at younger ages, vaccination can prevent some future infections in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae394","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:39:31Z","timestamp":1723059571000},"page":"751-761","source":"Crossref","is-referenced-by-count":12,"title":["Vaccine Effectiveness Against Anal HPV Among Men Who Have Sex With Men Aged 18\u201345 Years Attending Sexual Health Clinics in 3 United States Cities, 2018\u20132023"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-7070","authenticated-orcid":false,"given":"Carla L","family":"DeSisto","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy D","family":"Querec","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damilola","family":"Dada","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Pathela","sequence":"additional","affiliation":[{"name":"Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene , New York City, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Asbel","sequence":"additional","affiliation":[{"name":"Division of Disease Control, Philadelphia Department of Public Health , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tang","sequence":"additional","affiliation":[{"name":"Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene , New York City, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Public Health Laboratory , Prevention Division, Seattle and King County Department of Public Health, Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Meites","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R","family":"Unger","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri E","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"2025031709160285600_jiae394-B1","doi-asserted-by":"crossref","first-page":"e531","DOI":"10.1016\/S2352-3018(21)00108-9","article-title":"Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies","volume":"8","author":"Wei","year":"2021","journal-title":"Lancet HIV"},{"key":"2025031709160285600_jiae394-B2","first-page":"1","article-title":"Quadrivalent human 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