{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:35:24Z","timestamp":1793378124275,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL152161"],"award-info":[{"award-number":["R01HL152161"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic norovirus infection (CNI) causes significant morbidity in immunocompromised patients. No effective prevention or treatment currently exists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two patients with inborn errors of immunity, X-linked severe combined immunodeficiency (X-SCID) and DOCK8 deficiency, were followed longitudinally for clinical course, immune reconstitution, norovirus-specific T-cell (NST) response, B-cell reconstitution, and norovirus-specific antibody production. Samples were obtained in the peri-hematopoietic stem cell transplant (HSCT) setting before and after CNI clearance. The norovirus strain causing CNI was followed longitudinally for norovirus stool viral loads and sequencing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The noroviruses were identified as GII.4 Sydney[P4 New Orleans] in 1 patient and GII.17[P17] in the other. An exacerbation of diarrhea post-HSCT in the patient with X-SCID was consistent with norovirus infection but not with graft-versus-host disease on pathologic samples. Both patients recovered polyfunctional NSTs in the CD4 and CD8 T-cell compartments that recognized multiple norovirus structural and nonstructural viral antigens. T-cell responses were minimal during active CNI but detectable after resolution. Mapping of NST responses between the patient with DOCK8 deficiency and his matched sibling donor were nearly identical. B-cell reconstitution or new endogenous antibody production for immunoglobulin A or immunoglobulin G was not observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This report is the first to demonstrate reconstitution of NST immunity after HSCT closely temporally aligned with clearance of CNI, suggesting that cellular immunity is sufficient for norovirus clearance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae398","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T10:29:46Z","timestamp":1723631386000},"page":"773-783","source":"Crossref","is-referenced-by-count":6,"title":["Reconstitution of Norovirus-Specific T-Cell Responses Following Hematopoietic Stem Cell Transplantation in Patients With Inborn Errors of Immunity and Chronic Norovirus Infection"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-6881","authenticated-orcid":false,"given":"Jessica","family":"Durkee-Shock","sequence":"first","affiliation":[{"name":"Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariella","family":"Cohen","sequence":"additional","affiliation":[{"name":"Center for Cancer and Immunology Research, Children\u2019s National Hospital , Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Maghzian","sequence":"additional","affiliation":[{"name":"Center for Cancer and Immunology Research, Children\u2019s National Hospital , Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Pezzella","sequence":"additional","affiliation":[{"name":"Center for Cancer and Immunology Research, Children\u2019s National Hospital , Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Jensen-Wachspress","sequence":"additional","affiliation":[{"name":"Center for Cancer and Immunology Research, Children\u2019s National Hospital , Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hostal","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karenna","family":"Barton","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, Division of 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, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca M","family":"Nagata","sequence":"additional","affiliation":[{"name":"Infectious Disease Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases , Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derron A","family":"Alves","sequence":"additional","affiliation":[{"name":"Infectious Disease Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases , Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Ghosh","sequence":"additional","affiliation":[{"name":"NIAID Centralized Sequencing Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce 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