{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:33:29Z","timestamp":1792002809929,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2305201"],"award-info":[{"award-number":["2022YFC2305201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072272"],"award-info":[{"award-number":["82072272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373651"],"award-info":[{"award-number":["82373651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202311015"],"award-info":[{"award-number":["SZSM202311015"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK064"],"award-info":[{"award-number":["SZXK064"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Shenzhen, a city with a substantial mobile population, was identified as the first discovered region of human immunodeficiency virus-1 (HIV-1) CRF55_01B and epicenter of its severe epidemic. During the implementation of venue-based behavioral interventions and the \u201ctreat-all\u201d policy, identifying the patterns of spread and transmission hotspots of CRF55_01B is imperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 1450 partial pol sequences, with demographic information, were collected from all newly diagnosed CRF55_01B infections in Shenzhen from 2008 to 2020. Molecular networks were constructed using the maximum likelihood and time-resolve phylogenies. Transmission rates, effective reproduction numbers (Re) of clusters, and viral dispersal were evaluated using Bayesian inference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 526 sequences formed 114 clusters, including 7 large clusters. The status and size of clusters were strongly correlated with age, ethnicity, occupation, and CD4+ T-cell counts. The transmission rates of clusters were significantly higher than the national epidemic estimate. Four large clusters had Re exceeding 1 at the end of the sampling period. Immigrants from Guangdong and Hunan, along with local residents, were identified as the transmission hubs, with heterosexual men being the main source and MSM being the main destination. The virus exhibited a high movement frequency from individuals aged 30\u201349 years toward diverse age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that the hidden CRF55_01B transmissions continued despite current combined interventions in Shenzhen, and at-risk individuals susceptible to infection or transmission were identified, potentially serving as targets for more effective prevention and control of the local epidemic, thereby mitigating cross-regional spread nationwide due to population migration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiae428","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T13:46:17Z","timestamp":1724766377000},"page":"137-146","source":"Crossref","is-referenced-by-count":6,"title":["Sustained Spread of HIV-1 CRF55_01B in its Place of Origin: Dynamics and Hotspots"],"prefix":"10.1093","volume":"231","author":[{"given":"Minghui","family":"An","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University , Shenyang ,","place":["China"]},{"name":"Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-8518","authenticated-orcid":false,"given":"Chenli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University , Shenyang ,","place":["China"]},{"name":"Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University , Shenyang ,","place":["China"]},{"name":"Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-8943","authenticated-orcid":false,"given":"Hong","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University , Shenyang ,","place":["China"]},{"name":"Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2025020417113538400_jiae428-B1","author":"Shenzhen Municipal Bureau of 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The early spread and epidemic ignition of HIV-1 in human populations","volume":"346","author":"Faria","year":"2014","journal-title":"Science"},{"key":"2025020417113538400_jiae428-B25","doi-asserted-by":"crossref","first-page":"veab094","DOI":"10.1093\/ve\/veab094","article-title":"Independent epidemic patterns of HIV-1 CRF01_AE lineages driven by mobile population in Shenzhen, an immigrant city of China","volume":"7","author":"An","year":"2021","journal-title":"Virus Evol"},{"key":"2025020417113538400_jiae428-B26","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/jac\/dkad175","article-title":"Increased prevalence and stable clustering rate of HIV-1 transmitted drug resistance strains after \u2018treat-all\u2019 in a megacity of China","volume":"78","author":"Zhang","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"2025020417113538400_jiae428-B27","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3390\/ijerph17051469","article-title":"Mapping the spatial-temporal distribution and migration patterns of men who have sex with men in Mainland China: a web-based study","volume":"17","author":"Huang","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"2025020417113538400_jiae428-B28","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/cid\/ciw167","article-title":"Hidden and mobile: a web-based study of migration patterns of men who have sex with men in China","volume":"62","author":"Mi","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2025020417113538400_jiae428-B29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/OLQ.0000000000001602","article-title":"Estimation of the proportion of potential nondisclosed men who have sex with men among self-reported heterosexual men with HIV using a randomized response technique","volume":"49","author":"Chen","year":"2022","journal-title":"Sex Transm Dis"},{"key":"2025020417113538400_jiae428-B30","doi-asserted-by":"crossref","first-page":"e0283031","DOI":"10.1371\/journal.pone.0283031","article-title":"Inferring potential non-disclosed men who have sex with men among self-reported heterosexual men with HIV in Southwest China: a genetic network study","volume":"18","author":"Chen","year":"2023","journal-title":"PLoS One"},{"key":"2025020417113538400_jiae428-B31","doi-asserted-by":"crossref","first-page":"769535","DOI":"10.3389\/fmed.2021.769535","article-title":"The viral founder effect and economic-driven human mobility shaped the distinct epidemic pattern of HIV-1 CRF01_AE in Northeast China","volume":"8","author":"An","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2025020417113538400_jiae428-B32","doi-asserted-by":"crossref","first-page":"943","DOI":"10.46234\/ccdcw2023.177","article-title":"Trends in mortality and prevalence of reported HIV\/AIDS cases\u2014China, 2002\u20132021","volume":"5","author":"Dou","year":"2023","journal-title":"China CDC Wkly"},{"key":"2025020417113538400_jiae428-B33","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1038\/s41598-020-61870-x","article-title":"Tracing the transmission dynamics of HIV-1 CRF55_01B","volume":"10","author":"Zai","year":"2020","journal-title":"Sci Rep"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae428\/59087537\/jiae428.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/1\/137\/59087537\/jiae428.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/1\/137\/59087537\/jiae428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T12:13:32Z","timestamp":1738671212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/231\/1\/137\/7745051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,8,29]]},"published-print":{"date-parts":[[2025,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae428","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1,15]]},"published":{"date-parts":[[2024,8,29]]}}}