{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T10:01:15Z","timestamp":1772272875461,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health","doi-asserted-by":"publisher","award":["U01 AI168630"],"award-info":[{"award-number":["U01 AI168630"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health","doi-asserted-by":"publisher","award":["R21HD106579"],"award-info":[{"award-number":["R21HD106579"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Hospitals Cleveland Medical Center Clinical Research Center"},{"DOI":"10.13039\/100012729","name":"Clinical and Translational Science Collaborative of Cleveland","doi-asserted-by":"publisher","award":["UL1TR002548)"],"award-info":[{"award-number":["UL1TR002548)"]}],"id":[{"id":"10.13039\/100012729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"(NIH)"},{"DOI":"10.13039\/501100001677","name":"NIH Roadmap for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study examined the changes in the lipidome and associations with immune activation and cardiovascular disease (CVD) markers in youth with perinatally acquired human immunodeficiency virus (YPHIV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The serum lipidome was measured in antiretroviral therapy (ART)\u2013treated YPHIV (n = 100) and human immunodeficiency virus\u2013uninfected children (n = 98) in Uganda. Plasma markers of systemic inflammation, monocyte activation, gut integrity, and T-cell activation, as well as common carotid artery intima media thickness and pulse wave velocity (PWV), were evaluated at baseline and 96 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, median age was 12 years, and 52% were females. Total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein were similar between the groups; however, the concentrations of ceramides, diacylglycerols, free fatty acids, lysophosphatidylcholines, and phosphatidylcholines were higher in YPHIV (P \u2264 .03). Increases in phosphatidylethanolamine (16:0 and 18:0) correlated with increases in soluble CD163, oxidized LDL, C-reactive protein, intestinal fatty acid binding protein, and PWV in YPHIV (r \u2265 0.3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>YPHIV successfully suppressed on ART have elevated lipid species that are associated with CVD, specifically palmitic acid (C16:0) and stearic acid (C18:0).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae461","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T19:40:48Z","timestamp":1727293248000},"page":"403-413","source":"Crossref","is-referenced-by-count":3,"title":["Changes in the Lipidome Are Associated With Immune Activation and Subclinical Vascular Disease in Youth With Human Immunodeficiency Virus in Uganda"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-9062","authenticated-orcid":false,"given":"Sahera","family":"Dirajlal-Fargo","sequence":"first","affiliation":[{"name":"Pediatric Infectious Disease, Ann and Robert Lurie Children\u2018s Hospital, Northwestern University Feinberg School of Medicine , Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melica","family":"Nikahd","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, Ohio State University , Columbus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Ailstock","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, Ohio State University , Columbus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath","family":"Manubolu","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, Ohio State University , Columbus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Musiime","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Makerere University"},{"name":"Joint Clinical Research Center , Kampala ,","place":["Uganda"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cissy","family":"Kityo","sequence":"additional","affiliation":[{"name":"Joint Clinical Research Center , Kampala ,","place":["Uganda"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace A","family":"McComsey","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas T","family":"Funderburg","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, Ohio State University , 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