{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:29:45Z","timestamp":1785817785320,"version":"3.56.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"US Department of the Army, the US Department of Defense, or the US Department of Health and Human Services"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests that additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.<\/jats:p>","DOI":"10.1093\/infdis\/jiae515","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T10:51:07Z","timestamp":1729248667000},"page":"1069-1073","source":"Crossref","is-referenced-by-count":18,"title":["Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-4336","authenticated-orcid":false,"given":"Christopher N","family":"Selverian","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5031-2534","authenticated-orcid":false,"given":"Stephanie R","family":"Monticelli","sequence":"additional","affiliation":[{"name":"Viral Immunology Branch, Virology Division, United States Army Medical Research Institute of Infectious Diseases , Fort Detrick, Maryland"},{"name":"The Geneva Foundation , Tacoma, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5484-2760","authenticated-orcid":false,"given":"Yakin M","family":"Jaleta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-323X","authenticated-orcid":false,"given":"Gorka","family":"Lasso","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-4207","authenticated-orcid":false,"given":"Megan E","family":"DeMouth","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Meola","sequence":"additional","affiliation":[{"name":"Department of Virology, G5 Structural Biology of Infectious Diseases, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Berrigan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2086-794X","authenticated-orcid":false,"given":"Thomas G","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Viral Immunology Branch, Virology Division, United States Army Medical Research Institute of Infectious Diseases , Fort Detrick, Maryland"},{"name":"Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Battini","sequence":"additional","affiliation":[{"name":"Department of Virology, G5 Structural Biology of Infectious Diseases, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Guardado-Calvo","sequence":"additional","affiliation":[{"name":"Department of Virology, G5 Structural Biology of Infectious Diseases, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"Herbert","sequence":"additional","affiliation":[{"name":"Viral Immunology Branch, Virology Division, United States Army Medical Research Institute of Infectious Diseases , Fort Detrick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-7077","authenticated-orcid":false,"given":"Kartik","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-6548","authenticated-orcid":false,"given":"Eric","family":"Meyerowitz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center"},{"name":"Department of Medicine, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Happy","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York"},{"name":"Department of Medicine, Albert Einstein College of Medicine , Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"2025041514215380400_jiae515-B1","author":"World Health Organization","year":"2024"},{"key":"2025041514215380400_jiae515-B2","first-page":"465","article-title":"Human monkeypox: secondary attack rates","volume":"66","author":"Jezek","year":"1988","journal-title":"Bull World Health Organ"},{"key":"2025041514215380400_jiae515-B3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.15585\/mmwr.mm7122e1","article-title":"Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2022","volume":"71","author":"Rao","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025041514215380400_jiae515-B4","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJMoa1817307","article-title":"Phase 3 efficacy trial of modified vaccinia Ankara as a vaccine against smallpox","volume":"381","author":"Pittman","year":"2019","journal-title":"N Engl J Med"},{"key":"2025041514215380400_jiae515-B5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.15585\/mmwr.mm7220a3","article-title":"Estimated effectiveness of JYNNEOS vaccine in preventing mpox: a multijurisdictional case-control study\u2014United States, August 19, 2022\u2013March 31, 2023","volume":"72","author":"Dalton","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025041514215380400_jiae515-B6","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cell.2024.02.003","article-title":"Underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic","volume":"187","author":"Paredes","year":"2024","journal-title":"Cell"},{"key":"2025041514215380400_jiae515-B7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.15585\/mmwr.mm7225a6","article-title":"Notes from the field: emergence of an mpox cluster primarily affecting persons previously vaccinated against mpox\u2014Chicago, Illinois, March 18\u2013June 12, 2023","volume":"72","author":"Faherty","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025041514215380400_jiae515-B8","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1038\/s41591-024-03130-3","article-title":"Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo","volume":"30","author":"Vakaniaki","year":"2024","journal-title":"Nat Med"},{"key":"2025041514215380400_jiae515-B9","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3390\/v2051050","article-title":"Surf and turf: mechanism of enhanced virus spread during poxvirus infection","volume":"2","author":"Condit","year":"2010","journal-title":"Viruses"},{"key":"2025041514215380400_jiae515-B10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-065X.2010.00975.x","article-title":"Smallpox vaccines: targets of protective immunity","volume":"239","author":"Moss","year":"2011","journal-title":"Immunol Rev"},{"key":"2025041514215380400_jiae515-B11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S1473-3099(23)00352-3","article-title":"Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study","volume":"23","author":"Cohn","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2025041514215380400_jiae515-B12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41591-022-02090-w","article-title":"Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals","volume":"29","author":"Zaeck","year":"2023","journal-title":"Nat Med"},{"key":"2025041514215380400_jiae515-B13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nm1273","article-title":"Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox","volume":"11","author":"Hammarlund","year":"2005","journal-title":"Nat Med"},{"key":"2025041514215380400_jiae515-B14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41577-022-00775-4","article-title":"Monkeypox: disease epidemiology, host immunity and clinical interventions","volume":"22","author":"Lum","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2025041514215380400_jiae515-B15","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1016\/j.cell.2024.08.043","article-title":"Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates","volume":"187","author":"Mucker","year":"2024","journal-title":"Cell"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae515\/60421074\/jiae515.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/4\/1069\/60421074\/jiae515.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/4\/1069\/60421074\/jiae515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T14:52:03Z","timestamp":1744728723000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/231\/4\/1069\/7826114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10,18]]},"published-print":{"date-parts":[[2025,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae515","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4,15]]},"published":{"date-parts":[[2024,10,18]]}}}