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We previously reported that iHEU have decreased maternal microchimerism (MMc)\u2014maternal cells transferred to the offspring in utero\/during breastfeeding. We quantified MMc in T-cell subpopulations in iHEU and HIV-unexposed infants (iHU) to determine whether a selective deficiency in MMc contributes to altered cellular immunity. Across all infants, MMc levels were highest in CD8+ T cells; however, the level of CD8+ T-cell MMc was lower in iHEU versus iHU. In limited functional studies, we did not identify cytomegalovirus-specific MMc during infant primary infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiae521","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:21:45Z","timestamp":1729264905000},"page":"435-439","source":"Crossref","is-referenced-by-count":4,"title":["Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-3955","authenticated-orcid":false,"given":"Blair","family":"Armistead","sequence":"first","affiliation":[{"name":"Center for Global Infectious Disease Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Quinn","family":"Peters","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease 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,","place":["South Africa"]},{"name":"Department of Global Health, University of Washington , Seattle"},{"name":"Department of Pediatrics, University of Washington , Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-978X","authenticated-orcid":false,"given":"Whitney E","family":"Harrington","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research"},{"name":"Department of Global Health, University of Washington , Seattle"},{"name":"Department of Pediatrics, University of Washington , Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"2026041420075646000_jiae521-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fped.2018.00157","article-title":"Surviving and thriving-shifting the public health response to HIV-exposed uninfected children: report of the 3rd HIV-exposed uninfected 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