{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:05:56Z","timestamp":1788894356406,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170009"],"award-info":[{"award-number":["82170009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102403"],"award-info":[{"award-number":["82102403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Plan","award":["2021YFA1300902"],"award-info":[{"award-number":["2021YFA1300902"]}]},{"name":"Guangdong Science Fund for Distinguished Young Scholars","award":["0620220214"],"award-info":[{"award-number":["0620220214"]}]},{"name":"State Key Laboratory of Respiratory Diseases Open Project","award":["SKLRD-OP-202324"],"award-info":[{"award-number":["SKLRD-OP-202324"]}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["KCXFZ20211020163545004"],"award-info":[{"award-number":["KCXFZ20211020163545004"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["RCJC20221008092726022"],"award-info":[{"award-number":["RCJC20221008092726022"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["JCYJ20220530163216036"],"award-info":[{"award-number":["JCYJ20220530163216036"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019341","name":"Shenzhen Scientific and Technological Foundation","doi-asserted-by":"publisher","award":["JCYJ20220818095610021"],"award-info":[{"award-number":["JCYJ20220818095610021"]}],"id":[{"id":"10.13039\/501100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZZYSM202311009"],"award-info":[{"award-number":["SZZYSM202311009"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Scientific and Technological Foundation","award":["AA22096027"],"award-info":[{"award-number":["AA22096027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberculosis caused by Mycobacterium tuberculosis (Mtb), results in significant disease and death worldwide. Host-directed therapy, including conventional drugs, is a promising antituberculosis strategy that shows synergistic antibacterial effects when combined with antituberculosis drugs. Here, the mycobactericidal effect of 3 antidiabetic drugs was examined. Of these, only troglitazone (Trog) enhanced the antimycobacterial effect in vitro and in vivo. This was due to Trog-mediated autophagy activation. Moreover, a knock-down experiment revealed that Trog activated autophagy and exhibited antimycobacterial activity through the serine\/threonine-protein kinase STK11 (LKB1)-5'-AMP-activated protein kinase (AMPK) signaling pathway. Molecular docking and coimmunoprecipitation experiments demonstrated that Trog promoted LKB1 phosphorylation and activation by targeting STE20-related kinase adapter protein alpha (STRADA). Finally, we found that Trog inhibited the intracellular survival of clinical isoniazid-resistant Mtb, and the combination of Trog and isoniazid showed additive antibacterial effects against Mtb H37Rv. Taken together, antidiabetic Trog may be repurposed as a candidate for host-directed therapy and combined with first-line antituberculosis drugs.<\/jats:p>","DOI":"10.1093\/infdis\/jiae523","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T23:22:32Z","timestamp":1729639352000},"page":"e553-e565","source":"Crossref","is-referenced-by-count":8,"title":["Troglitazone Reduction of Intracellular\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Survival Via Macrophage Autophagy Through LKB1-AMPK\u03b1 Signaling"],"prefix":"10.1093","volume":"231","author":[{"given":"Jing","family":"Bi","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Gong","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojia","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqin","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiean","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Pingshan Translational Medicine Center , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenran","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Pingshan Translational Medicine Center , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Guangxi Chest Hospital , Liuzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobao","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-5449","authenticated-orcid":false,"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"2025031709172176500_jiae523-B1","author":"World Health Organization. Global tuberculosis report 2023"},{"key":"2025031709172176500_jiae523-B2","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/S1473-3099(16)00078-5","article-title":"Host-directed therapies for infectious diseases: current status, recent progress, and future prospects","volume":"16","author":"Zumla","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2025031709172176500_jiae523-B3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O'Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2025031709172176500_jiae523-B4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41423-020-0502-z","article-title":"New insights into the evasion of host innate immunity by Mycobacterium tuberculosis","volume":"17","author":"Chai","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2025031709172176500_jiae523-B5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/21505594.2018.1536598","article-title":"Autophagy: a new strategy for host-directed therapy of tuberculosis","volume":"10","author":"Paik","year":"2019","journal-title":"Virulence"},{"key":"2025031709172176500_jiae523-B6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41564-023-01335-9","article-title":"ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages","volume":"8","author":"Aylan","year":"2023","journal-title":"Nat Microbiol"},{"key":"2025031709172176500_jiae523-B7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2019.04.012","article-title":"LC3-associated phagocytosis: host defense and microbial response","volume":"60","author":"Upadhyay","year":"2019","journal-title":"Curr Opin Immunol"},{"key":"2025031709172176500_jiae523-B8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrd.2017.162","article-title":"Host-directed therapies for bacterial and viral infections","volume":"17","author":"Kaufmann","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2025031709172176500_jiae523-B9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"key":"2025031709172176500_jiae523-B10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nri3813","article-title":"Advancing host-directed therapy for tuberculosis","volume":"15","author":"Wallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2025031709172176500_jiae523-B11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat Genet"},{"key":"2025031709172176500_jiae523-B12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/mp4006563","article-title":"Inhalable particles containing rapamycin for induction of autophagy in macrophages infected with Mycobacterium tuberculosis","volume":"11","author":"Gupta","year":"2014","journal-title":"Mol Pharm"},{"key":"2025031709172176500_jiae523-B13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/347645a0","article-title":"Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators","volume":"347","author":"Issemann","year":"1990","journal-title":"Nature"},{"key":"2025031709172176500_jiae523-B14","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nri912","article-title":"Emerging roles of PPARs in inflammation and immunity","volume":"2","author":"Daynes","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2025031709172176500_jiae523-B15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3892\/mmr.2021.12069","article-title":"The antidiabetic drug troglitazone protects against PrP (106\u2013126)\u2013induced neurotoxicity via the PPAR\u03b3\u2013autophagy pathway in neuronal cells","volume":"23","author":"Moon","year":"2021","journal-title":"Mol Med Rep"},{"key":"2025031709172176500_jiae523-B16","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.biocel.2009.06.007","article-title":"PPAR\u03b3 activation induces autophagy in breast cancer cells","volume":"41","author":"Zhou","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"2025031709172176500_jiae523-B17","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.tube.2016.09.008","article-title":"Metformin: candidate host-directed therapy for tuberculosis in diabetes and non-diabetes patients","volume":"101S","author":"Restrepo","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"key":"2025031709172176500_jiae523-B18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diabetes.49.4.539","article-title":"Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone","volume":"49","author":"Camp","year":"2000","journal-title":"Diabetes"},{"key":"2025031709172176500_jiae523-B19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/auto.6.1.10437","article-title":"Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling","volume":"6","author":"Yan","year":"2010","journal-title":"Autophagy"},{"key":"2025031709172176500_jiae523-B20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/cgt.2014.16","article-title":"The PPAR\u03b3 agonist troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells","volume":"21","author":"Yan","year":"2014","journal-title":"Cancer Gene Ther"},{"key":"2025031709172176500_jiae523-B21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI7145","article-title":"A novel therapy for colitis utilizing PPAR-\u03b3 ligands to inhibit the epithelial inflammatory response","volume":"104","author":"Su","year":"1999","journal-title":"J Clin Invest"},{"key":"2025031709172176500_jiae523-B22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.neuron.2017.01.026","article-title":"Bassoon controls presynaptic autophagy through Atg5","volume":"93","author":"Okerlund","year":"2017","journal-title":"Neuron"},{"key":"2025031709172176500_jiae523-B23","doi-asserted-by":"crossref","first-page":"e00124-20","DOI":"10.1128\/mSphere.00124-20","article-title":"Bazedoxifene suppresses intracellular Mycobacterium tuberculosis growth by enhancing autophagy","volume":"5","author":"Ouyang","year":"2020","journal-title":"mSphere"},{"key":"2025031709172176500_jiae523-B24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nature16451","article-title":"Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection","volume":"528","author":"Kimmey","year":"2015","journal-title":"Nature"},{"key":"2025031709172176500_jiae523-B25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat Cell Biol"},{"key":"2025031709172176500_jiae523-B26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"2025031709172176500_jiae523-B27","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1178377","article-title":"Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation","volume":"326","author":"Zeqiraj","year":"2009","journal-title":"Science"},{"key":"2025031709172176500_jiae523-B28","doi-asserted-by":"crossref","first-page":"e1000126","DOI":"10.1371\/journal.pbio.1000126","article-title":"ATP and MO25\u03b1 regulate the conformational state of the STRAD\u03b1 pseudokinase and activation of the LKB1 tumour suppressor","volume":"7","author":"Zeqiraj","year":"2009","journal-title":"PLoS Biol"},{"key":"2025031709172176500_jiae523-B29","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.jinf.2020.03.003","article-title":"Ibrutinib suppresses intracellular Mycobacterium tuberculosis growth by inducing macrophage autophagy","volume":"80","author":"Hu","year":"2020","journal-title":"J Infect"},{"key":"2025031709172176500_jiae523-B30","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/JLB.4A0221-119RR","article-title":"Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation","volume":"111","author":"Mo","year":"2022","journal-title":"J Leukoc Biol"},{"key":"2025031709172176500_jiae523-B31","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1038\/s41598-017-09702-3","article-title":"Pioglitazone enhances cytosolic lipolysis, \u03b2-oxidation and autophagy to ameliorate hepatic steatosis","volume":"7","author":"Hsiao","year":"2017","journal-title":"Sci Rep"},{"key":"2025031709172176500_jiae523-B32","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.3892\/mmr.2015.4292","article-title":"Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury","volume":"12","author":"Yao","year":"2015","journal-title":"Mol Med Rep"},{"key":"2025031709172176500_jiae523-B33","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.cell.2013.11.019","article-title":"Autophagy-mediated tumor promotion","volume":"155","author":"Guo","year":"2013","journal-title":"Cell"},{"key":"2025031709172176500_jiae523-B34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2012.06.040","article-title":"Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway","volume":"150","author":"Watson","year":"2012","journal-title":"Cell"},{"key":"2025031709172176500_jiae523-B35","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41564-023-01354-6","article-title":"Autophagy restricts Mycobacterium tuberculosis during acute infection in mice","volume":"8","author":"Golovkine","year":"2023","journal-title":"Nat Microbiol"},{"key":"2025031709172176500_jiae523-B36","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chom.2012.03.008","article-title":"Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action","volume":"11","author":"Kim","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2025031709172176500_jiae523-B37","doi-asserted-by":"crossref","first-page":"e55692","DOI":"10.7554\/eLife.55692","article-title":"The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection","volume":"9","author":"Giraud-Gatineau","year":"2020","journal-title":"Elife"},{"key":"2025031709172176500_jiae523-B38","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","article-title":"LKB1 is the upstream kinase in the AMP-activated protein kinase cascade","volume":"13","author":"Woods","year":"2003","journal-title":"Curr Biol"},{"key":"2025031709172176500_jiae523-B39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-981-15-0602-4_4","article-title":"AMPK and autophagy","volume":"1206","author":"Li","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"2025031709172176500_jiae523-B40","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ncb1537","article-title":"The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis","volume":"9","author":"Liang","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2025031709172176500_jiae523-B41","doi-asserted-by":"crossref","first-page":"15637","DOI":"10.1038\/ncomms15637","article-title":"WIPI3 and WIPI4 \u03b2-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy","volume":"8","author":"Bakula","year":"2017","journal-title":"Nat Commun"},{"key":"2025031709172176500_jiae523-B42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/imr.12255","article-title":"New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics","volume":"264","author":"Hawn","year":"2015","journal-title":"Immunol Rev"},{"key":"2025031709172176500_jiae523-B43","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/S1473-3099(18)30110-5","article-title":"Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies","volume":"18","author":"Tiberi","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2025031709172176500_jiae523-B44","doi-asserted-by":"crossref","first-page":"e0025321","DOI":"10.1128\/AAC.00253-21","article-title":"Dual mTORC1\/mTORC2 inhibition as a host-directed therapeutic target in pathologically distinct mouse models of tuberculosis","volume":"65","author":"Tasneen","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2025031709172176500_jiae523-B45","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.chom.2011.09.010","article-title":"Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis","volume":"10","author":"Napier","year":"2011","journal-title":"Cell Host Microbe"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae523\/60643297\/jiae523.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/3\/e553\/60643297\/jiae523.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/3\/e553\/60643297\/jiae523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T05:18:00Z","timestamp":1742188680000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/231\/3\/e553\/7840797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,10,25]]},"published-print":{"date-parts":[[2025,3,17]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae523","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3,15]]},"published":{"date-parts":[[2024,10,25]]}}}