{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:07:21Z","timestamp":1787854041274,"version":"build-2784847793"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011054","name":"Danida","doi-asserted-by":"publisher","award":["12-081RH"],"award-info":[{"award-number":["12-081RH"]}],"id":[{"id":"10.13039\/501100011054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011054","name":"Danida","doi-asserted-by":"publisher","award":["17-02-KU"],"award-info":[{"award-number":["17-02-KU"]}],"id":[{"id":"10.13039\/501100011054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["0134-00123B"],"award-info":[{"award-number":["0134-00123B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["1721"],"award-info":[{"award-number":["1721"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Program","doi-asserted-by":"publisher","award":["FP7-HEALTH-2012-INNOVATION"],"award-info":[{"award-number":["FP7-HEALTH-2012-INNOVATION"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Program","doi-asserted-by":"publisher","award":["200889"],"award-info":[{"award-number":["200889"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acquired immunity to Plasmodium falciparum malaria is mainly mediated by immunoglobulin G (IgG) targeting erythrocyte membrane protein 1 (PfEMP1). These adhesins mediate infected erythrocyte (IE) sequestration, protecting IEs from splenic destruction. PfEMP1-specific IgG is therefore thought to protect mainly by inhibiting IE sequestration. VAR2CSA-type PfEMP1 mediates placental IE sequestration, putting pregnant women exposed to P falciparum parasites at risk of placental malaria (PM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Levels and Fc-afucosylation of VAR2CSA-specific plasma IgG were measured by a modified enzyme-linked immunosorbent assay (FEASI). We also measured the ability of the IgG to inhibit IE adhesion and to induce natural killer (NK) cell degranulation. The results were related to parity and clinical pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Parity was positively correlated with levels and Fc-afucosylation of VAR2CSA-specific IgG, and with birth weight and plasma IgG inhibition of IE adhesion in vitro. Fc-afucosylation of VAR2CSA-specific IgG increased NK\u2013cell degranulation. Women with Fc-afucosylated VAR2CSA\u2013specific IgG had a reduced risk of delivering a low birth weight (LBW) baby, but not of PM or anemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fc-afucosylated VAR2CSA-specific IgG effectively induced NK\u2013cell degranulation and was associated with protection against LBW, independent of IgG levels. Our study has implications for the development of VAR2CSA-based subunit vaccines, which exclusively induce Fc-fucosylated IgG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiae529","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T14:43:46Z","timestamp":1732545826000},"page":"e956-e965","source":"Crossref","is-referenced-by-count":8,"title":["Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental <i>Plasmodium falciparum<\/i> Malaria"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-0248","authenticated-orcid":false,"given":"Mary","family":"Lopez-Perez","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0542-3171","authenticated-orcid":false,"given":"Firmine","family":"Viwami","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin , Abomey Calavi, Benin"},{"name":"M\u00e8re et Enfant en Milieu Tropical, Institut de Recherche pour le D\u00e9veloppement , Universit\u00e9 de Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-7449","authenticated-orcid":false,"given":"Paulina","family":"Ampomah","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-6803","authenticated-orcid":false,"given":"Ton\u0107i","family":"\u0160u\u0161ti\u0107","sequence":"additional","affiliation":[{"name":"Immunoglobulin Research Laboratory, Sanquin Research , Amsterdam"},{"name":"Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-5901","authenticated-orcid":false,"given":"Mads Delbo","family":"Larsen","sequence":"additional","affiliation":[{"name":"Immunoglobulin Research Laboratory, Sanquin Research , Amsterdam"},{"name":"Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-4995","authenticated-orcid":false,"given":"Manfred","family":"Wuhrer","sequence":"additional","affiliation":[{"name":"Center for Proteomics and Metabolomics, Leiden University Medical Center ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-003X","authenticated-orcid":false,"given":"Gestur","family":"Vidarsson","sequence":"additional","affiliation":[{"name":"Immunoglobulin Research Laboratory, Sanquin Research , Amsterdam"},{"name":"Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-7514","authenticated-orcid":false,"given":"Michael F","family":"Ofori","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana , Accra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-2513","authenticated-orcid":false,"given":"Nicaise","family":"Tuikue Ndam","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin , Abomey Calavi, Benin"},{"name":"M\u00e8re et Enfant en Milieu Tropical, Institut de Recherche pour le D\u00e9veloppement , Universit\u00e9 de Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen ,","place":["Denmark"]},{"name":"Department of Infectious Diseases, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"2025060208123058400_jiae529-B1","volume-title":"World malaria report 2023","author":"World Health Organization (WHO)","year":"2023"},{"key":"2025060208123058400_jiae529-B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.apar.2024.02.001","article-title":"PfEMP1 and var genes\u2014still of key importance in Plasmodium falciparum malaria pathogenesis and immunity","volume":"125","author":"Hviid","year":"2024","journal-title":"Adv Parasitol"},{"key":"2025060208123058400_jiae529-B3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chom.2017.02.009","article-title":"Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria","volume":"21","author":"Lennartz","year":"2017","journal-title":"Cell Host Microbe"},{"key":"2025060208123058400_jiae529-B4","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.20041579","article-title":"Evidence for the involvement of VAR2CSA in pregnancy-associated malaria","volume":"200","author":"Salanti","year":"2004","journal-title":"J Exp Med"},{"key":"2025060208123058400_jiae529-B5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/192733a0","article-title":"Gamma-globulin and acquired immunity to human malaria","volume":"192","author":"Cohen","year":"1961","journal-title":"Nature"},{"key":"2025060208123058400_jiae529-B6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1126\/science.2417315","article-title":"Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants","volume":"231","author":"Marsh","year":"1986","journal-title":"Science"},{"key":"2025060208123058400_jiae529-B7","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1172\/JCI62182","article-title":"Targets of antibodies against Plasmodium falciparum\u2013infected erythrocytes in malaria immunity","volume":"122","author":"Chan","year":"2012","journal-title":"J Clin Invest"},{"key":"2025060208123058400_jiae529-B8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1473-3099(07)70022-1","article-title":"Malaria in pregnancy: pathogenesis and immunity","volume":"7","author":"Rogerson","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2025060208123058400_jiae529-B9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/27570","article-title":"Maternal antibodies block malaria","volume":"395","author":"Fried","year":"1998","journal-title":"Nature"},{"key":"2025060208123058400_jiae529-B10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1586\/erv.11.113","article-title":"The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria","volume":"10","author":"Hviid","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"2025060208123058400_jiae529-B11","doi-asserted-by":"crossref","first-page":"23332","DOI":"10.1074\/jbc.M112.348839","article-title":"Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria","volume":"287","author":"Clausen","year":"2012","journal-title":"J Biol Chem"},{"key":"2025060208123058400_jiae529-B12","doi-asserted-by":"crossref","first-page":"634508","DOI":"10.3389\/fimmu.2021.634508","article-title":"Progress and insights toward an effective placental malaria vaccine","volume":"12","author":"Gamain","year":"2021","journal-title":"Front Immunol"},{"key":"2025060208123058400_jiae529-B13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.it.2015.04.005","article-title":"Fc\u03b3r dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities","volume":"36","author":"Nimmerjahn","year":"2015","journal-title":"Trends Immunol"},{"key":"2025060208123058400_jiae529-B14","doi-asserted-by":"crossref","first-page":"26733","DOI":"10.1074\/jbc.M202069200","article-title":"Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fc\u03b3RIII and antibody-dependent cellular toxicity","volume":"277","author":"Shields","year":"2002","journal-title":"J Biol Chem"},{"key":"2025060208123058400_jiae529-B15","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1038\/s41467-021-26118-w","article-title":"Afucosylated Plasmodium falciparum\u2013specific IgG is induced by infection but not by subunit vaccination","volume":"12","author":"Larsen","year":"2021","journal-title":"Nat Commun"},{"key":"2025060208123058400_jiae529-B16","doi-asserted-by":"crossref","first-page":"e36806","DOI":"10.7554\/eLife.36806","article-title":"NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity","volume":"7","author":"Arora","year":"2018","journal-title":"Elife"},{"key":"2025060208123058400_jiae529-B17","first-page":"13","article-title":"Pregnancy-associated malaria in a rural community of Ghana","volume":"43","author":"Ofori","year":"2009","journal-title":"Ghana Med J"},{"key":"2025060208123058400_jiae529-B18","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1128\/IAI.01514-13","article-title":"B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites","volume":"82","author":"Ampomah","year":"2014","journal-title":"Infect Immun"},{"key":"2025060208123058400_jiae529-B19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4269\/ajtmh.2011.11-0103","article-title":"Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin","volume":"85","author":"Huynh","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"2025060208123058400_jiae529-B20","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/s41598-017-01495-9","article-title":"Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria","volume":"7","author":"T\u00e9tard","year":"2017","journal-title":"Sci Rep"},{"key":"2025060208123058400_jiae529-B21","doi-asserted-by":"crossref","first-page":"e1005022","DOI":"10.1371\/journal.ppat.1005022","article-title":"\u03b12-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes","volume":"11","author":"Stevenson","year":"2015","journal-title":"PLoS Pathog"},{"key":"2025060208123058400_jiae529-B22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2958.2006.05503.x","article-title":"Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA","volume":"63","author":"Barfod","year":"2007","journal-title":"Mol Microbiol"},{"key":"2025060208123058400_jiae529-B23","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s41596-024-00963-7","article-title":"GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout","volume":"19","author":"Falck","year":"2024","journal-title":"Nat Protoc"},{"key":"2025060208123058400_jiae529-B24","doi-asserted-by":"crossref","first-page":"eabc8378","DOI":"10.1126\/science.abc8378","article-title":"Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity","volume":"371","author":"Larsen","year":"2021","journal-title":"Science"},{"key":"2025060208123058400_jiae529-B25","doi-asserted-by":"crossref","first-page":"104109","DOI":"10.1016\/j.ebiom.2022.104109","article-title":"Immunoassay for quantification of antigen-specific IgG fucosylation","volume":"81","author":"\u0160u\u0161ti\u0107","year":"2022","journal-title":"EBioMedicine"},{"key":"2025060208123058400_jiae529-B26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-0716-2189-9_5","article-title":"Establishing and maintaining in vitro cultures of asexual blood stages of Plasmodium falciparum","volume":"2470","author":"Lopez-Perez","year":"2022","journal-title":"Methods Mol Biol"},{"key":"2025060208123058400_jiae529-B27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-0716-2189-9_7","article-title":"Immunomagnetic selection of Plasmodium falciparum\u2013infected erythrocytes expressing particular PfEMP1 variants","volume":"2470","author":"Lopez-Perez","year":"2022","journal-title":"Methods Mol Biol"},{"key":"2025060208123058400_jiae529-B28","doi-asserted-by":"crossref","first-page":"ofab527","DOI":"10.1093\/ofid\/ofab527","article-title":"PfEMP1-specific immunoglobulin G reactivity among Beninese pregnant women with sickle cell trait","volume":"8","author":"Lopez-Perez","year":"2021","journal-title":"Open Forum Infect Dis"},{"key":"2025060208123058400_jiae529-B29","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.3389\/fimmu.2018.02873","article-title":"Expression of a recombinant high affinity IgG Fc receptor by engineered NK cells as a docking platform for therapeutic mAbs to target cancer cells","volume":"9","author":"Snyder","year":"2018","journal-title":"Front Immunol"},{"key":"2025060208123058400_jiae529-B30","doi-asserted-by":"crossref","first-page":"872","DOI":"10.4161\/mabs.26307","article-title":"Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity","volume":"5","author":"Shatz","year":"2013","journal-title":"MAbs"},{"key":"2025060208123058400_jiae529-B31","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/imm.13737","article-title":"Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level","volume":"171","author":"de Graaf","year":"2024","journal-title":"Immunology"},{"key":"2025060208123058400_jiae529-B32","doi-asserted-by":"crossref","first-page":"eadd9012","DOI":"10.1126\/scitranslmed.add9012","article-title":"Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria","volume":"15","author":"Ty","year":"2023","journal-title":"Sci Transl Med"},{"key":"2025060208123058400_jiae529-B33","doi-asserted-by":"crossref","first-page":"621382","DOI":"10.3389\/fimmu.2021.621382","article-title":"Poor birth outcomes in malaria in pregnancy: recent insights into mechanisms and prevention approaches","volume":"12","author":"Chua","year":"2021","journal-title":"Front Immunol"},{"key":"2025060208123058400_jiae529-B34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(23)02511-4","article-title":"Safety and efficacy of malaria vaccine candidate R21\/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial","volume":"403","author":"Datoo","year":"2024","journal-title":"Lancet"},{"key":"2025060208123058400_jiae529-B35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1473-3099(23)00368-7","article-title":"Seasonal vaccination with RTS,S\/AS01(E) vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial","volume":"24","author":"Dicko","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2025060208123058400_jiae529-B36","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJMoa2206966","article-title":"Safety and efficacy of a monoclonal antibody against malaria in Mali","volume":"387","author":"Kayentao","year":"2022","journal-title":"N Engl J Med"},{"key":"2025060208123058400_jiae529-B37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/infdis\/jiy168","article-title":"Etiology of placental Plasmodium falciparum malaria in African women","volume":"218","author":"Ofori","year":"2018","journal-title":"J Infect Dis"},{"key":"2025060208123058400_jiae529-B38","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/cid\/ciy380","article-title":"Persistent Plasmodium falciparum infection in women with an intent to become pregnant as a risk factor for pregnancy-associated malaria","volume":"67","author":"Tuikue Ndam","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2025060208123058400_jiae529-B39","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00360-8","article-title":"Safety and efficacy of PfSPZ vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials [manuscript published online ahead of print 14 August 2024]","author":"Diawara","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2025060208123058400_jiae529-B40","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/cid\/ciy1140","article-title":"First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria","volume":"69","author":"Mordm\u00fcller","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2025060208123058400_jiae529-B41","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1473-3099(19)30739-X","article-title":"PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study","volume":"20","author":"Sirima","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"2025060208123058400_jiae529-B42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41564-020-00858-9","article-title":"Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA","volume":"6","author":"Ma","year":"2021","journal-title":"Nat Microbiol"},{"key":"2025060208123058400_jiae529-B43","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1038\/s41467-021-23254-1","article-title":"Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"2025060208123058400_jiae529-B44","doi-asserted-by":"crossref","first-page":"e1011370","DOI":"10.1371\/journal.ppat.1011370","article-title":"A conformational epitope in placental malaria vaccine antigen VAR2CSA: what does it teach us?","volume":"19","author":"Doritchamou","year":"2023","journal-title":"PLoS Pathog"},{"key":"2025060208123058400_jiae529-B45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12916-019-1467-6","article-title":"Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review","volume":"18","author":"Cutts","year":"2020","journal-title":"BMC Med"},{"key":"2025060208123058400_jiae529-B46","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1084\/jem.20181681","article-title":"Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria","volume":"216","author":"Hart","year":"2019","journal-title":"J Exp Med"},{"key":"2025060208123058400_jiae529-B47","doi-asserted-by":"crossref","first-page":"e65776","DOI":"10.7554\/eLife.65776","article-title":"Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria","volume":"10","author":"Aitken","year":"2021","journal-title":"Elife"},{"key":"2025060208123058400_jiae529-B48","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1073\/pnas.80.16.5075","article-title":"Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes","volume":"80","author":"David","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025060208123058400_jiae529-B49","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/bjh.12965","article-title":"Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn","volume":"166","author":"Kapur","year":"2014","journal-title":"Br J Haematol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiae529\/60750809\/jiae529.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/5\/e956\/60750809\/jiae529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/5\/e956\/60750809\/jiae529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:12:46Z","timestamp":1748866366000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/231\/5\/e956\/7904719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,11,25]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiae529","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5,15]]},"published":{"date-parts":[[2024,11,25]]}}}