{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:50:34Z","timestamp":1776873034153,"version":"3.51.2"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402661"],"award-info":[{"award-number":["82402661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30502"],"award-info":[{"award-number":["2023JJ30502"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ9409"],"award-info":[{"award-number":["2024JJ9409"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Fund of Hunan Provincial Education Department","award":["20A438"],"award-info":[{"award-number":["20A438"]}]},{"name":"Scientific Research Fund of Hunan Provincial Education Department","award":["22B0417"],"award-info":[{"award-number":["22B0417"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia psittaci is a zoonotic pathogen known to cause respiratory diseases in humans. Chlamydia infections are closely associated with apoptosis, in which microRNAs (miRNAs) play regulatory roles. Herein, we demonstrated that C. psittaci infection induces apoptosis in human bronchial epithelial (HBE) cells and investigated regulatory mechanism involving miR-124-3p and the PI3K\/AKT signaling pathway. Following C. psittaci infection in HBE cells, we observed an elevated HBE cell apoptosis, accompanied by upregulation of miR-124-3p levels. Mechanistically, we identified EIF3B as a novel target gene of miR-124-3p, supported by the inverse correlation of their mRNA expressions. MiR-124-3p inhibitor reduced apoptosis induced by C. psittaci, increased the replication of C. psittaci, and inhibited PI3K\/AKT activation, whereas miR-124-3p mimic produced opposite effects, and transfection with EIF3B siRNA reversed the effects of miR-124-3p inhibitor. Our findings suggest that miR-124-3p targeting EIF3B promotes apoptosis in C. psittaci-infected HBE cells through activation of the PI3K\/AKT signaling pathway.<\/jats:p>","DOI":"10.1093\/infdis\/jiae573","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:28:24Z","timestamp":1732040904000},"page":"1165-1175","source":"Crossref","is-referenced-by-count":3,"title":["MiR-124-3p\/<i>EIF3B<\/i> Regulates Host Cell Apoptosis Induced by <i>Chlamydia psittaci<\/i> Through PI3K\/AKT Signaling Pathway"],"prefix":"10.1093","volume":"231","author":[{"given":"Ting","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]},{"name":"Department of Microbiology, Liangping Center For Disease Control and Prevention , Liangping, Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Medical Records, Affiliated Nanhua Hospital, University of South China , Hengyang, Hunan Province ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saihong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hengyang Center for Disease Control and Prevention , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-1240","authenticated-orcid":false,"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China , Hengyang, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025060208125673900_jiae573-B1","doi-asserted-by":"crossref","first-page":"e0033723","DOI":"10.1128\/iai.00337-23","article-title":"MiR-184 targeting 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