{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:40:21Z","timestamp":1790912421809,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Health and Welfare, Republic of Korea"},{"DOI":"10.13039\/501100003710","name":"National Institute of Health, Republic of Korea","doi-asserted-by":"publisher","award":["2024ER170100"],"award-info":[{"award-number":["2024ER170100"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Japanese encephalitis (JE) has been predominantly controlled through vaccination. However, the isolation of JE virus (JEV) genotype V (GV) in China in 2009, and the subsequent alarming increase in JE cases in the Republic of Korea since 2010, present a new challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples from individuals vaccinated with genotype III (GIII)-based JE vaccines were analyzed for neutralizing seroresponse to GV isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum from immunocompromised pediatric patients vaccinated with an inactivated JE vaccine showed higher 50% plaque reduction neutralization test geometric mean titer (GMT) against GIII Nakayama (11 358; 95% confidence interval [CI], 1790\u201329 658), but lower GMTs against GV isolates: GV Muar (499; 95% CI, 0\u20132437), GV 43279 (308; 95% CI, 159\u2013582), and GV 43413 (231; 95% CI, 108\u2013738). Similarly, 32 healthy volunteers receiving a live attenuated JE vaccine achieved 100% seroprotection against GIII Nakayama with GMT of 338 (95% CI, 304\u2013651) at 1 month postvaccination. However, GMTs against GV isolates were 123 (95% CI, 102\u2013446) for GV Muar, 81 (95% CI, 63\u2013168) for GV 43279, and 107 (95% CI, 100\u2013322) for GV 43413, not achieving 100% seroprotection against these isolates. At 6 months postvaccination, GMT against Nakayama increased to 696 (95% CI, 409\u20132353), while remaining similar for GV isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study underscores that current GIII-based vaccines do not provide comparable protection against GV JEVs, impacting individuals in both current and potential endemic regions, as well as travelers to these regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiae589","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T23:23:43Z","timestamp":1732145023000},"page":"1281-1289","source":"Crossref","is-referenced-by-count":13,"title":["Genotype III-Based Japanese Encephalitis Vaccines Exhibit Diminished Neutralizing Response to Reemerging Genotype V"],"prefix":"10.1093","volume":"231","author":[{"given":"Ah-Ra","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Graduate School of The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Graduate School of The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeyoun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Graduate School of The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yeon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Graduate School of The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Mu","family":"Shim","sequence":"additional","affiliation":[{"name":"Division of Acute Virus Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency , Cheongju ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Vectors and Parasitic Diseases, Korea Disease Control and Prevention Agency , Cheongju ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Song","sequence":"additional","affiliation":[{"name":"School of Biopharmaceutical and Medical Sciences, Sungshin Women's University , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-2872","authenticated-orcid":false,"given":"Seong-Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology , Daejeon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7444-2738","authenticated-orcid":false,"given":"Tomohiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dokkyo Medical University School of Medicine , Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-4964","authenticated-orcid":false,"given":"Ji-Man","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Seok","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Center for Hematologic Malignancy, National Cancer Center , Goyang ,","place":["Republic of 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