{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:02:39Z","timestamp":1792188159656,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fellowship Programme of the European Centre for Disease Prevention and Control"},{"DOI":"10.13039\/501100004587","name":"National Institute of Health Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Acci\u00f3n Estrat\u00e9gica de Salud Intramural","award":["PI21CIII\/00029"],"award-info":[{"award-number":["PI21CIII\/00029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fluoroquinolone resistance in Shigella is among the serious antimicrobial resistance threats. We investigated the genomic epidemiology of fluoroquinolone-resistant (FQR) strains of S sonnei and S flexneri from 2015 to 2022 in Spain and Portugal. We determined the antimicrobial resistance profiles of 416 isolates (S flexneri and S sonnei), and FQR isolates were subjected to whole genome sequencing. The percentage of FQR isolates gradually increased to reach 38% and 80% of S flexneri and S sonnei isolates, respectively, in 2022. S sonnei isolates from men were significantly more likely to be FQR (relative risk, 4.9; 95% CI, 2.7\u20139.0). Genomic analysis revealed 2 major genetic clusters of FQR S sonnei from the CipR.MSM5 lineage, previously associated with extreme antimicrobial resistance and transmission in men having sex with men. This study contributes to a better understanding of FQR shigellosis transmission and highlights the added value of enhanced surveillance for these pathogens.<\/jats:p>","DOI":"10.1093\/infdis\/jiae596","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T15:16:41Z","timestamp":1732893401000},"page":"1176-1185","source":"Crossref","is-referenced-by-count":3,"title":["Genomic Epidemiology of Fluoroquinolone-Resistant Strains of <i>Shigella sonnei<\/i> and <i>Shigella flexneri<\/i> in the Iberian Peninsula From 2015 to 2022"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-7079","authenticated-orcid":false,"given":"Camille","family":"Jacqueline","sequence":"first","affiliation":[{"name":"Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III , Majadahonda ,","place":["Spain"]},{"name":"European Public Health Microbiology Training Programme, European Centre for Disease Prevention and Control , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Minetti","sequence":"additional","affiliation":[{"name":"European Public Health Microbiology Training Programme, European Centre for Disease Prevention and Control , Stockholm ,","place":["Sweden"]},{"name":"National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Monzon Fernandez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III , Majadahonda ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-3008","authenticated-orcid":false,"given":"Leonor","family":"Silveira","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cuesta De La Plaza","sequence":"additional","affiliation":[{"name":"Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III , Majadahonda ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-4222","authenticated-orcid":false,"given":"\u00c2ngela","family":"Pista","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Herrera-Leon","sequence":"additional","affiliation":[{"name":"Centro Nacional de Microbiolog\u00eda, 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