{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:37:57Z","timestamp":1790386677404,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Joint Programme on Rare Diseases"},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["308913"],"award-info":[{"award-number":["308913"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Life and Health Medical Support Association"},{"name":"The Sigrid Jus\u00e9lius Foundation"},{"name":"Helsinki University Hospital"},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004155","name":"Magnus Ehrnrooth Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myasthenia gravis (MG) is a rare autoimmune disorder characterized by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted next-generation sequencing and quantitative polymerase chain reaction to analyze thymic tissue samples from both patients with MG and healthy controls. We detected human herpes virus 6B and 7, Epstein-Barr virus, and parvovirus B19 (B19V) across various tissue groups. However, no significant enrichment of these viruses was observed in the thymic tissue of patients with MG.<\/jats:p>","DOI":"10.1093\/infdis\/jiae600","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T20:35:15Z","timestamp":1733862915000},"page":"e601-e606","source":"Crossref","is-referenced-by-count":3,"title":["Parvovirus B19 and Human Herpes Virus 6B and 7 Are Frequently Found DNA Viruses in the Human Thymus But Show No Definitive Link With Myasthenia Gravis"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-4823","authenticated-orcid":false,"given":"Kirsten","family":"Nowlan","sequence":"first","affiliation":[{"name":"Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Department of Bacteriology and Immunology, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5982-413X","authenticated-orcid":false,"given":"Leo","family":"Hannolainen","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6308-3530","authenticated-orcid":false,"given":"Irini M","family":"Assimakopoulou","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5996-2913","authenticated-orcid":false,"given":"Pia","family":"D\u00fcrnsteiner","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Department of Bacteriology and Immunology, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-0379","authenticated-orcid":false,"given":"Joona","family":"Sarkkinen","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Department of Bacteriology and Immunology, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1008-7816","authenticated-orcid":false,"given":"Santeri","family":"Suokas","sequence":"additional","affiliation":[{"name":"Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-2900","authenticated-orcid":false,"given":"Pentti J","family":"Tienari","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Department of Neurology, Neurocenter, Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-7960","authenticated-orcid":false,"given":"Klaus","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Clinical Microbiology, HUS Diagnostic Center, Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-9859","authenticated-orcid":false,"given":"Mikael","family":"Niku","sequence":"additional","affiliation":[{"name":"Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-1092","authenticated-orcid":false,"given":"Leena-Maija","family":"Aaltonen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5948","authenticated-orcid":false,"given":"Antti","family":"Huuskonen","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac and Transplantation Surgery Department, Helsinki Children's Hospital, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-532X","authenticated-orcid":false,"given":"Jari V","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of General Thoracic and Esophageal Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-3550","authenticated-orcid":false,"given":"Ilkka 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,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-2849","authenticated-orcid":false,"given":"Sini M","family":"Laakso","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]},{"name":"Department of Neurology, Neurocenter, Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-8317","authenticated-orcid":false,"given":"Maria","family":"S\u00f6derlund-Venermo","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9031-4251","authenticated-orcid":false,"given":"Maria 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