{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:51:49Z","timestamp":1794009109023,"version":"4.8.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"German Center for Infection Research","doi-asserted-by":"publisher","award":["TTU 01.702"],"award-info":[{"award-number":["TTU 01.702"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative 2 Joint Undertaking","doi-asserted-by":"publisher","award":["116088"],"award-info":[{"award-number":["116088"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017561","name":"FLI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017561","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VISION consortium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cells connect innate and adaptive immune responses. This is a particularly important immune checkpoint in the case of emerging infections against which most of the population does not have preexisting antibody immunity. In this study, we sought to test whether antibody-based delivery of Ebola virus (EBOV) antigens to dendritic cells could be used as a vaccination strategy against Ebola virus disease. Our approach was to use antibodies targeting the endocytic receptor DEC-205 present in murine and human dendritic cells, to deliver the EBOV nucleoprotein or the model antigen ovalbumin (OVA). Our findings indicate that DEC-205 targeting stimulated antigen-specific T-cell responses in mice, which resulted in protection from EBOV or recombinant EBOV-OVA challenge. An added value of this strategy was the generation of resident memory T cells. We propose that dendritic cell targeting could be used to improve T-cell responses against filoviruses, a strategy that may complement current vaccination strategies.<\/jats:p>","DOI":"10.1093\/infdis\/jiae613","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T13:40:12Z","timestamp":1737726012000},"page":"e615-e625","source":"Crossref","is-referenced-by-count":5,"title":["Antibody-Based Antigen Delivery to Dendritic Cells as a Vaccination Strategy Against Ebola Virus Disease"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2288-2026","authenticated-orcid":false,"given":"Catherine","family":"Olal","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , Hamburg"},{"name":"German Center for Infection Research, partner site Hamburg-Borstel-L\u00fcbeck-Riems , Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-9168","authenticated-orcid":false,"given":"Bianca S","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institut , Greifswald-Insel Riems"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Rottstegge","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , Hamburg"},{"name":"German Center for Infection Research, partner site Hamburg-Borstel-L\u00fcbeck-Riems , Hamburg"},{"name":"Institute for Infection Research and Vaccine Development, University Medical Centre Hamburg-Eppendorf , Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-0525","authenticated-orcid":false,"given":"Beatriz","family":"Escudero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Bernhard 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Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily V","family":"Nelson","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Heung","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-1079","authenticated-orcid":false,"given":"Stephanie","family":"Wurr","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Blake","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 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Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Gallais","sequence":"additional","affiliation":[{"name":"D\u00e9partement M\u00e9dicament et Technologie pour la Sant\u00e9, Service d\u2019Ing\u00e9nierie Mol\u00e9culaire pour la Sant\u00e9, Universit\u00e9 Paris-Saclay, Commissariat \u00e1 l\u2019\u00e9nergie atomique et aux \u00e9nergies alternatives-Saclay , Gif sur Yvette"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3144-8652","authenticated-orcid":false,"given":"Fabienne","family":"Anju\u00e8re","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7275, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1323, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire , Valbonne 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