{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:31:45Z","timestamp":1791952305749,"version":"4.3.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2017\/02203-7"],"award-info":[{"award-number":["2017\/02203-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/10599-3"],"award-info":[{"award-number":["2021\/10599-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/00527-5"],"award-info":[{"award-number":["2021\/00527-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/01975-4"],"award-info":[{"award-number":["2022\/01975-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI141794-01A1"],"award-info":[{"award-number":["R01AI141794-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida albicans catheter-related candidemia is largely driven by microbial adhesion and biofilm formation on central venous catheters. Cells that disperse from these biofilms can enter the bloodstream, spread to distant organs, and sustain the cycle of infection. In this study, we investigated the virulence potential of C. albicans isolates obtained from the blood of catheterized patients experiencing persistent candidemia, comparing them to isolates that were cleared from the bloodstream early in the infection. Our results show that isolates persisting in the bloodstream for 4 days or longer, despite antifungal treatment, exhibited enhanced adherence, filamentation, and biofilm formation in vitro, along with increased expression of key virulence-related genes. Notably, cells dispersed from second-generation biofilms formed by these persistent isolates displayed even more pronounced pathogenic characteristics, including improved immune evasion. Furthermore, in vivo experiments using Galleria mellonella revealed that persistent isolates were significantly more virulent than their nonpersistent counterparts.<\/jats:p>","DOI":"10.1093\/infdis\/jiae631","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T15:27:16Z","timestamp":1734449236000},"page":"e803-e812","source":"Crossref","is-referenced-by-count":11,"title":["<i>Candida albicans<\/i>\n                    Recovered From Persistent Candidemia Exhibits Enhanced Virulence Traits"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-3243","authenticated-orcid":false,"given":"Felipe de Camargo","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline Kristina","family":"Kemmerich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-432X","authenticated-orcid":false,"given":"Juliana Caparroz","family":"Gon\u00e7ale","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University , S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Campos","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University , S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo 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Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]},{"name":"The Antimicrobial Resistance Institute of S\u00e3o Paulo , Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-054X","authenticated-orcid":false,"given":"Priya","family":"Uppuluri","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center , Torrance, California ,","place":["USA"]},{"name":"David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California 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